Coupling an injectable gel and MSC microtissues to enhance cartilage repair

将注射凝胶与 MSC 微组织结合以增强软骨修复

• 批准号: nhmrc : GNT1083857
• 负责人: A/Pr Michael Doran
• 金额: $ 51.64万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/coupling-an-injectable-cartilage-repair/1345527
• 关键词: Coupling; injectable; gel; MSC; microtissues

Osteoarthritis (OA) is the most common cause of pain and disability in Australia. The OVERALL AIM of this project is to use a photo-activated hydrogel containing growth factors and stem cell-derived cartilage microtissues to repair cartilage defects. The gel and small diameter microtissues combination makes this innovative repair process compatible with less invasive and less costly orthoscopic surgical procedures. Effective cartilage defect repair will delay or prevent the onset of OA.

骨关节炎（OA）是澳大利亚最常见的疼痛和残疾原因。本项目的总体目标是使用含有生长因子和干细胞衍生的软骨微组织的光活化水凝胶来修复软骨缺损。凝胶和小直径微组织的组合使这种创新的修复过程与侵入性更小、成本更低的矫形外科手术兼容。有效的软骨缺损修复将延迟或预防OA的发作。