The Microniche: A novel in-vitro and in-vivo prostate cancer model system

Microniche：一种新型的体外和体内前列腺癌模型系统

• 批准号: nhmrc : 1108043
• 负责人: A/Pr Michael Doran
• 金额: $ 38.44万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microniche-novel-in-cancer-model/663016
• 关键词: Microniche; novel; vitro; vivo; prostate

Maintaining primary prostate cancer cells (PCa) in vitro remains an enormous challenge for the field, and this obstructs efforts to systematically characterize cell behaviour and quantify drug response. Our group recently developed a 3-demsensional (3D) organoid culture system that does maintain PCa in vitro, and here we will integrate this technology with our 3D bone maorrow niche model system to better characterize PCa bone metastases and identify new clinical treatment regimes.

在体外维持原代前列腺癌细胞（PCa）仍然是该领域的一个巨大挑战，这阻碍了系统地表征细胞行为和量化药物反应的努力。我们小组最近开发了一种能够在体外维持 PCa 的 3 维 (3D) 类器官培养系统，在这里我们将这项技术与我们的 3D 骨髓生态位模型系统相结合，以更好地表征 PCa 骨转移并确定新的临床治疗方案。