ROLE OF BETA-ADRENOCEPTOR IN THE HYPOPHOSPHATURIA OF ACUTE HYPOCAPNIA IN HUMANS

β-肾上腺素受体在人类急性低碳酸血症的低磷酸盐尿中的作用

• 批准号: 3764867
• 负责人: M J JOYNER
• 金额: --
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3764867
• 关键词: beta adrenergic receptor; clearance rate; human subject; hyperpnea; hypocapnia; phosphorus metabolism disorders; propranolol

To determine if acute hypocapnia without accompanying hypoxia causes hypophosphaturia, and if this can be prevented by Beta-adrenoreceptor blockade. Renal clearance studies will be done under conditions of normocapnia, voluntary hyperventilation with normocapnia, and voluntary hyperventilation with hypocapnia before and after propranolol administration.

为了确定急性低碳酸血症不伴缺氧是否会导致 低磷酸盐尿，如果β-肾上腺素受体可以预防 封锁 肾清除率研究将在以下条件下进行： 正常碳酸血症、正常碳酸血症的自主过度通气和自主过度通气 心得安治疗前后过度通气伴低碳酸血症 局