FEEDBACK ACTIONS AND METABOLIC CLEARANCE RATE OF IGF I
FEEDBACK ACTIONS AND METABOLIC CLEARANCE RATE OF IGF I
批准号:
6279356
负责人:
JOHANNES D VELDHUIS
金额:
$3.19万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30
中文摘要
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英文摘要
This study in older men and women tests two hypotheses: (i) the insulin-
like growth factor, IGF, suppresses growth hormone (GH) less in the
presence of sex-steroid hormones than in their absence; and (ii) sex-
steroid hormones increase the metabolic clearance rate of IGF-I, but not
GH. Low dose IGF-I fails to suppress GH in women (5 evaluated). We are
completing assessment of the corresponding protocol in men.
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