Phosphorus Masquerading as a Metal

申请人在她的职业生涯中有着出色的业绩记录，并在国际上享有越来越高的声誉。该方案利用合成化学技术，以廉价和高可用性的元素为基础，提供环境友好型催化剂。现代社会中90%的化学品都需要催化剂来生产。催化剂通常由昂贵和稀缺的过渡金属制成，例如钯和铂。由主族元素（如磷）制成的催化剂是有吸引力的替代品，因为成本更低，可用性更高。过渡金属是很好的催化剂，因为它们可以在多个稳定的氧化态之间循环，并且可以将几个小分子聚集在一起，使它们能够添加。相比之下，主基团催化剂通常一次只激活一个小分子，并且有一个初级氧化态。我们提出，通过将主族元素聚集在一起，它们将相互合作，以更好地模拟过渡金属的配位和氧化还原能力。我们最近的研究结果表明这是可能的。这解决了开发可与过渡金属催化剂相媲美的主基团催化剂的主要限制。我们将：-准备将多个小分子聚集在一起的簇。-发展氧化还原化学，将两个小分子偶联在一起，从而介导新的成键反应。-开发串联激活不同类型分子的簇，并将它们加在一起。-整合加成和氧化还原键形成化学，以获得复杂的催化途径，例如级联催化。这个具有凝聚力和创新性的项目为合成科学提供了一个多样化的工具来组装支撑日常生活的分子，例如药品、电子产品和燃料。P_Cat有可能从根本上改变未来主要基团催化剂的设计方式，从而重新定义最先进的技术。该项目为“欧洲绿色协议”优先领域提供了支持，并提供了高素质的科学家。

The applicant has an outstanding track-record for her career stage and growing international reputation. This proposal uses synthetic chemistry to provide environment-friendly catalysts based on cheap and highly available elements.Catalysts are required to produce 90% of all chemicals used in modern societies. Catalysts are often made of expensive and scarce transition metals, e.g. palladium and platinum. Catalysts made of main group elements, e.g. phosphorus, are attractive alternatives because of lower costs and greater availability. Transition metals are great catalysts because they can cycle between multiple stable oxidation states and can bring together several small molecules, enabling their addition. In contrast, main group catalysts generally only activate one small molecule at a time and have one primary oxidation state. We propose that by clustering main group elements together they will cooperate to better emulate the coordination and redox abilities of transition metals. Our recent results show that this is possible. This addresses the major limitations in developing main group catalysts that can rival transition metal catalysts.We will:-Prepare clusters that bring together multiple small molecules.-Develop the redox chemistry necessary to couple two small molecules together, thus mediating new bond forming reactions.-Develop clusters that tandem activate different types of molecules and add them together.-Integrate the addition and redox bond formation chemistries to access complex catalysis pathways, e.g. cascade catalysis.This cohesive and innovative project provides synthesis science with a diverse tool to assemble the molecules that underpin everyday life, e.g. pharmaceuticals, electronics and fuels. P_Cat has the potential to fundamentally change the way that future main group catalysts are designed, thus redefining the state-of-the-art.This project feeds into priority area 'A European Green Deal' and delivers high-calibre scientists.