Phosphorus Masquerading as a Metal

伪装成金属的磷

• 批准号: EP/Y037391/1
• 负责人: Meera Mehta
• 金额: $ 166.32万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY037391%2F1
• 关键词: Phosphorus; Masquerading; Metal

The applicant has an outstanding track-record for her career stage and growing international reputation. This proposal uses synthetic chemistry to provide environment-friendly catalysts based on cheap and highly available elements.Catalysts are required to produce 90% of all chemicals used in modern societies. Catalysts are often made of expensive and scarce transition metals, e.g. palladium and platinum. Catalysts made of main group elements, e.g. phosphorus, are attractive alternatives because of lower costs and greater availability. Transition metals are great catalysts because they can cycle between multiple stable oxidation states and can bring together several small molecules, enabling their addition. In contrast, main group catalysts generally only activate one small molecule at a time and have one primary oxidation state. We propose that by clustering main group elements together they will cooperate to better emulate the coordination and redox abilities of transition metals. Our recent results show that this is possible. This addresses the major limitations in developing main group catalysts that can rival transition metal catalysts.We will:-Prepare clusters that bring together multiple small molecules.-Develop the redox chemistry necessary to couple two small molecules together, thus mediating new bond forming reactions.-Develop clusters that tandem activate different types of molecules and add them together.-Integrate the addition and redox bond formation chemistries to access complex catalysis pathways, e.g. cascade catalysis.This cohesive and innovative project provides synthesis science with a diverse tool to assemble the molecules that underpin everyday life, e.g. pharmaceuticals, electronics and fuels. P_Cat has the potential to fundamentally change the way that future main group catalysts are designed, thus redefining the state-of-the-art.This project feeds into priority area 'A European Green Deal' and delivers high-calibre scientists.

应聘者在事业发展阶段和日益增长的国际声誉方面有着出色的记录。这项建议使用合成化学来提供基于廉价和高度可用元素的环境友好型催化剂。现代社会使用的所有化学品中，90%需要催化剂来生产。催化剂通常由昂贵而稀缺的过渡金属制成，例如钯和铂。由主要族元素制成的催化剂，如磷，由于成本较低和可获得性较高，是有吸引力的替代品。过渡金属是很好的催化剂，因为它们可以在多种稳定的氧化态之间循环，并可以将几个小分子聚集在一起，使它们能够加成。相比之下，主族催化剂通常一次只激活一个小分子，并且有一个初级氧化态。我们认为，通过将主族元素聚集在一起，它们将进行合作，以更好地模拟过渡金属的配位和氧化还原能力。我们最近的结果表明，这是可能的。这解决了开发可与过渡金属催化剂竞争的主族催化剂的主要限制。我们将：-准备将多个小分子聚集在一起的簇。-开发将两个小分子连接在一起所需的氧化还原化学，从而调节新的键形成反应。-开发串联激活不同类型的分子并将它们添加到一起的簇。-整合加成和氧化还原键形成化学以访问复杂的催化途径，例如级联催化剂。这一具有凝聚力的创新项目为合成科学提供了一种多样化的工具，以组装支撑日常生活的分子，如制药、电子和燃料。P_Cat有可能从根本上改变未来主要基团催化剂的设计方式，从而重新定义最先进的技术。该项目将为优先领域‘欧洲绿色交易’提供支持，并培养高素质的科学家。