SEQUELAE OF TRANSFUSION AND DONATION

输血和捐献的后遗症

• 批准号: 3765850
• 负责人: DALE C ALVERSON
• 金额: --
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3765850
• 关键词: antigen presentation; biomarker; blood transfusion; human subject; immunity; infant human (0-1 year); leukocyte activation /transformation; lymphocyte proliferation; natural killer cells; opsonin; plasmapheresis; plateletpheresis; preschool child (1-5)

This project will study the immunologic sequelae of transfusion and plasma and platelet donation by apheresis. This study will concentrate on newborn infants because they have demonstrated a greater incidence of transfusion-associated AIDS. Cell markers, lymphocyte proliferation assays, opsonic activity, natural killer cells and activity and response to antigen stimulation will be evaluated up to 3 years after transfusion.

该项目将研究输血和输血的免疫后遗症 通过单采术捐献血浆和血小板。 本次研究将集中 新生儿，因为他们的发病率更高 与输血相关的艾滋病。 细胞标志物、淋巴细胞增殖 测定、调理活性、自然杀伤细胞以及活性和反应 输血后 3 年内将对抗原刺激进行评估。