Creatine supplementation during pregnancy as a means of improving outcomes from preterm birth.

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Preterm birth results in significant health problems for babies, especially males who are more likely to die. We have shown that creatine added to the mother’s diet protects the fetus against damage caused by oxygen lack at the end of pregnancy. We will now determine if creatine can benefit babies born prematurely. We have an established model of preterm birth in lambs in which we will address these issues, and expect to show that creatine improves survival and the health of the preterm neonate.