ORAL MUCOSAL DISEASE IN AGING

该提案描述了一项关于在 由五人组成的爱荷华大学老年口腔健康研究 三核支持的研究项目。该计划的总体目标 中心就是要提供适当的智力和物质环境 支持优秀的基础研究，为 探讨老龄化过程中口腔健康的重大问题。的关注点 这项研究将增加对口腔粘膜疾病的了解 在老年人中，这将通过一系列具有凝聚力的四个 跨学科项目： 项目1老年人的口腔粘膜损害 项目3：念珠菌毒力与人类老化 项目4人乳头瘤病毒与口腔癌的病因学 项目5抗氧化酶在口腔癌中的作用 这些项目将得到两个核心的支持；实验设计和 生物统计核心将与所有项目对接并协助 实验设计、数据录入和统计分析。组织 文化核心将提供设施、专业知识和技术支持 对于研究涉及细胞和组织的体外模型的研究人员 在文化上。 总体而言，该中心将支持一个针对疾病的研究方案 对老年人的口腔健康至关重要，以便 提供治疗和最终预防的方法。

The proposal describes an application to establish a Research Center on Oral Health in Aging at The University of Iowa consisting of five research projects supported by three cores. The overall goal of the Center is to provide an appropriate intellectual and physical environment to support outstanding basic research that will provide a foundation for approaching significant problems of oral health in aging. The focus of the research will be to increase understanding of oral mucosal disease in the elderly, which will be accomplished by a cohesive series of four interdisciplinary projects: Project 1 Oral Mucosal Lesions Among the Elderly Project 3 Candidal Virulence and Human Aging Project 4 Human Papilloma Virus and the Etiology of Oral Cancer Project 5 Role of Antioxidant Enzymes in Oral Cancer The projects will be supported by two cores; The Experimental Design and Biostatistics Core will interface with all projects and assist in experimental design, data entry, and statistical analysis. The Tissue Cultural Core will offer facilities, expertise, and technical support for investigators working with in vitro models involving cells and tissue in culture. Overall, the Center will support a program of research aimed at diseases of fundamental importance in the oral health of the elderly so as to offer approaches to therapy and eventually prevention.