PERINATAL EMPHASIS RESEARCH CENTER GRANT

围产期重点研究中心拨款

• 批准号: 3106250
• 负责人: REGINALD C TSANG
• 金额: $ 50.13万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106250
• 关键词: perinatal; prenatal growth disorder

The long-term objective of the Center is to optimize fetal and neonatal growth and to decrease fetal and infant morbidity and mortality. These goals will be accomplished by defining and understanding the basic physiology of fetal and neonatal growth and growth retardation. The overall thesis examined is that specific growth factors are principal regulators of growth and development of the fetus and infant. Drs. Tsang, Clark, Handwerger, and Whitsett provide the administrative organizational framework for the PERC. The Molecular Core provides a central site for molecular norphologic studies and training in in situ hybridization and immunocytochemistry, directed by Dr. Jeff Whitsett. Drs. Korfhagen and Whitsett will identify a progenitor during branching morphogenesis and Type II cytodifferentiation in the fetal lung. Drs. Weaver and Drake will test the hypothesis that the temporal and spatial regulation of pulmonary glycogen metabolism, in the developing respiratory epithelium, is correlated with the pre-translational regulation of glycogen synthase (Project B) and phosphorylase kinase (Project A). Dr. Lieberman examines the thesis that injections of neonatal rats with epidermal growth factor alters ontogenic expression of fibroblast growth factors (FGFs). Drs. Hoath and Donnelly test the thesis that perturbations of perinatal growth; i.e. placental insufficiency or exposure to exogenous EGF, will alter molecular events of early homeothermic adaptation in brown adipose tissue and imprint aberrant patterns of metabolic function in adults. Drs. Chernausek and Smith examine the thesis that carrier proteins for insulin- like growth factors are physiologically-regulated modulators of IGF action during the perinatal period. Dr. Iwamoto tests the hypothesis that the placenta and fetal liver regulated plasma concentrations of IGF-I and thus coordinate fetal growth. Dr. Clark tests the thesis that chronic reduced uteroplacental blood flow leads to asymmetric growth retardation and reduced IGF-I by altering delivery and uptake of oxygen, glucose, and amino acids by the placenta and fetus while also testing the thesis that direct fetal supplementation with nutrients and maternal oxygen administration can prevent IUGR. Thus in this Center, molecular biologic, cellular, physiologic, and a clinical study complement each other in an integrated multidisciplinary study.

该中心的长期目标是优化胎儿和新生儿 生长并降低胎儿和婴儿的发病率和死亡率。 这些 目标将通过定义和理解基本内容来实现 胎儿和新生儿生长和生长迟缓的生理学。 这 总体而言，研究的主题是特定的生长因素是主要的 胎儿和婴儿生长发育的调节剂。 博士。曾, Clark、Handwerger 和 Whitsett 提供行政组织 PERC 框架。 分子核心为 分子形态学研究和原位杂交培训 免疫细胞化学，由 Jeff Whitsett 博士指导。 博士。科尔夫哈​​根和 Whitsett 将在分支形态发生和类型过程中识别祖细胞 II 胎儿肺中的细胞分化。 博士。韦弗和德雷克将进行测试 假设肺的时间和空间调节 在发育中的呼吸道上皮中，糖原代谢是 与糖原合成酶的翻译前调节相关 （项目 B）和磷酸化酶激酶（项目 A）。 利伯曼博士检查 论文：给新生大鼠注射表皮生长因子 改变成纤维细胞生长因子 (FGF) 的个体发育表达。 博士。 霍斯和唐纳利检验了围产期生长扰动的论文； 即胎盘功能不全或暴露于外源性EGF，会改变 棕色脂肪组织早期恒温适应的分子事件 并印记成人代谢功能的异常模式。 博士。 Chernusek 和 Smith 研究了胰岛素载体蛋白的论文 生长因子等是 IGF 作用的生理调节调节剂 在围产期。 岩本博士检验了以下假设： 胎盘和胎儿肝脏调节 IGF-I 的血浆浓度，因此 协调胎儿生长。 克拉克博士测试了慢性减少的论点 子宫胎盘血流导致不对称生长迟缓 通过改变氧、葡萄糖和氨基的输送和摄取来减少 IGF-I 胎盘和胎儿产生的酸，同时还测试了直接的论文 胎儿补充营养和母体供氧可以 预防IUGR。 因此，在这个中心，分子生物学、细胞学、 生理学和临床研究在综合中相互补充 多学科研究。