PERSEVERATION IN APHASIA

长期目标：这项提议是一个计划的一部分，该计划结合了 临床和基础研究目标，长期目标是 阐明失语症患者的脑行为关系。的确有 新出现的证据表明，坚持不懈是某些 失语症综合征，可能是评估和评估的主要威慑因素 失语症患者的康复。这里的重点是 失语症患者沟通障碍的持久度及其影响 对坚持不懈和语言能力的治疗。 这项拟议的研究旨在：1)测试两个最常被引用的 关于复发的潜在机制的假说 失语症中的持久化，即语义记忆痕迹的后激活 在短期记忆与运动记忆痕迹；2)研究的影响 对失语症持续性的具体治疗；3)研究患者的 有持之以恒的反应意识；4)质的和 定量绘制患者坚持不懈的演变历程 接受坚持治疗的人与没有接受治疗的人 因坚持而接受治疗。

Long Term Objective: This proposal is part o a program that combines clinical and basic research objectives, with the long term goal of elucidating brain-behavior relationships in aphasic patients. There is emerging evidence that perseveration is an integral component of some aphasia syndromes, and can be a major deterrent to evaluation and rehabilitation of aphasic individuals. The focus here is on the role of perseveration in the communication breakdown in aphasia and the effects of treatment on perseveration and language performance. The proposed research aims: 1) to test the two most commonly cited hypotheses regarding the underlying mechanisms responsible for recurrent perseveration in aphasia, i.e. post-activitation of semantic memory traces in short term memory versus motor memory traces; 2) to study the effects of specific treatment on aphasic perseveration; 3) to study patients' awareness of perseverative responses; and 4) to qualitatively and quantitatively chart the evolutionary course of perseveration in patients who receive specific treatment for perseveration versus those who do not receive treatment for perseveration.