International Centre for Enzyme Design (ICED)

国际酶设计中心 (ICED)

• 批准号: EP/Z531157/1
• 负责人: Anthony Green
• 金额: $ 162.53万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FZ531157%2F1
• 关键词: International; Centre; Enzyme; Design; ICED

Biocatalysis is a sustainable technology that harnesses the power of Nature's catalysts, known as enzymes, to perform chemical reactions. Enzymes are inexpensive, biodegradable, produced from renewable feedstocks, operate under environmentally benign reaction conditions and speed up chemical processes with remarkable efficiency and selectivity. For these reasons, the chemical and pharmaceutical industries routinely use certain classes of enzymes in commercial manufacturing processes to replace chemical transformations that are inefficient and/or have a high environmental burden. For example, engineered enzymes are now used to produce pharmaceuticals and agrochemicals, recycle plastics and capture carbon dioxide from the atmosphere, thus contributing to a more efficient and sustainable chemical industry. However, enzymes found in Nature are usually not suitable for use in industrial applications and must first be optimized to improve properties such as catalytic efficiency, selectivity, and stability. Directed evolution is a powerful and versatile technology for adapting enzymes to make them suitable for use in commercial processes, but it is a costly and time-consuming process that requires specialist instrumentation only available in a handful of labs. Moreover, many chemical processes use non-natural reactions for which there are no known enzymes that can serve as starting templates for optimization. In this application, we will establish The International Centre for Enzyme Design (ICED), bringing together world leaders in computational protein design, enzyme engineering and industrial biocatalysis, to change the way that industrial biocatalysts are developed in the future. ICED will establish a fully integrated computational and experimental program, integrating the latest deep learning protein design tools with advanced experimental methods for enzyme engineering, to allow the reliable and predictable design of new and improved enzymes with a wide range of useful activities. In this way, ICED will deliver a step-change needed in the field to allow the rapid design of customized biocatalysts in response to diverse societal needs.

生物催化是一种可持续发展的技术，利用自然界的催化剂，即酶的力量来进行化学反应。酶是廉价的，可生物降解的，由可再生原料生产，在环境友好的反应条件下操作，并以显着的效率和选择性加速化学过程。由于这些原因，化学和制药工业通常在商业制造过程中使用某些类别的酶来代替低效和/或具有高环境负担的化学转化。例如，工程酶现在被用于生产药品和农用化学品，回收塑料和从大气中捕获二氧化碳，从而促进更有效和可持续的化学工业。然而，自然界中发现的酶通常不适合用于工业应用，必须首先进行优化以提高催化效率，选择性和稳定性等性能。定向进化是一种强大而通用的技术，可以使酶适应商业过程，但这是一个昂贵而耗时的过程，需要仅在少数实验室中可用的专业仪器。此外，许多化学过程使用非天然反应，其中没有已知的酶可以作为优化的起始模板。在此申请中，我们将建立国际酶设计中心（ICED），汇集计算蛋白质设计，酶工程和工业生物催化领域的世界领导者，以改变未来工业生物催化剂的开发方式。ICED将建立一个完全集成的计算和实验程序，将最新的深度学习蛋白质设计工具与先进的酶工程实验方法相结合，以实现可靠和可预测的新酶和改进酶的设计，并具有广泛的有用活性。通过这种方式，ICED将提供该领域所需的一个步骤，以允许快速设计定制的生物催化剂，以满足不同的社会需求。