ADVANCING CHILD HEALTH THROUGH CELL/MOLECULAR BIOLOGY

通过细胞/分子生物学促进儿童健康

• 批准号: 3103148
• 负责人: ROBERT P KELCH
• 金额: $ 27.79万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103148
• 关键词: Downs syndrome; biomedical facility; child (0-11); computer assisted sequence analysis; computer program /software; cystic fibrosis; health science research; malabsorption; mental retardation; microscopy; molecular biology; nucleic acid sequence; pediatric neoplasm /cancer; polymerase chain reaction; protein sequence; scintillation counter; training; ultracentrifugation; university

Advancing Child Health Through Cell/Molecular Biology is the overall theme of the University of Michigan's Child Health Research Center. The goal of the UM CHRC is to increase the number and effectiveness of pediatric scientists through an interdepartmental approach which will provide superb mentorship by well-established cell/molecular biologists located in basic science and clinical departments as well as within the Howard Hughes Medical Institute, an extensive array of core laboratory facilities and services, and ongoing institutional and departmental commitments. The Department of Pediatrics has a long tradition of excellence in research and in the training of academic pediatricians. During the last 20 years and especially during the last decade, the department expanded the scope of its research interests, activities, and accomplishments to a remarkable degree. The department decided to build upon its strong programs in clinical physiology and to play a major role in the medical school's plan to further develop research programs in clinically relevant areas of cell and molecular biology. The rationale underlying this commitment is the firm belief that major advances in the therapy and prevention of most congenital and acquired disorders of childhood will only be possible when cellular and molecular etiologies are known. To meet our objective a large cohort of senior and junior investigators have been recruited and/or trained, scientifically-oriented fellowship training guidelines and programs have been developed and adhered to, extensive intra- and interdepartmental collaborative efforts have been fostered, and significant resources have been committed to allow for the needed expansion of physical and human resources. Moreover, the necessary administrative systems and mentorship have been established to provide additional training and guidance of junior faculty to ensure their success as independent investigators. Current research activities of senior fellows and junior faculty, all of whom are under the guidance of established investigators, are aimed toward acquiring an understanding of the basic cause(s) of such troubling disorders as childhood cancer, genetic and acquired forms of mental retardation and Down syndrome, cystic fibrosis, congenital and acquired abnormalities in the production or function of white and red blood cells, molecular pathogenesis of microbial diseases, and several forms of malabsorption. Support provided by this grant will significantly amplify the department's ability to increase the number and quality of well trained pediatric scientists by allowing us to more thoroughly utilize the remarkable scientific strengths and resources of our center; and in so doing, it will help meet a crucial need of children.

通过细胞/分子生物学促进儿童健康是总的主题 密歇根大学儿童健康研究中心的。的目标是 UM CHRC将增加儿科医生的数量和有效性 科学家通过跨部门的方法将提供极好的 由位于Basic的知名细胞/分子生物学家指导 科学系和临床系以及霍华德·休斯夫妇 医学研究所，广泛的核心实验室设施和 服务，以及持续的机构和部门承诺。这个 儿科有着悠久的研究和卓越的传统 在学术儿科医生的培训方面。在过去的20年里， 特别是在过去十年中，司法部扩大了其工作范围 研究兴趣、活动和成就达到显著水平。 该部门决定在其强大的临床项目基础上再接再厉 并在医学院的计划中发挥重要作用 开发临床相关领域的细胞和 分子生物学。这一承诺背后的理由是公司 认为大多数先天性心脏病的治疗和预防方面的主要进展 儿童获得性障碍只有在细胞和 分子病因是已知的。为了达到我们的目标，一大批 已经招聘和/或培训了高级和初级调查员， 以科学为导向的团契培训指导方针和方案 制定并遵守了广泛的部门内和部门间 促进了合作努力，并提供了大量资源 一直致力于允许必要的物质和人力扩展 资源。此外，必要的行政制度和指导制度 已经成立，为青少年提供额外的培训和指导 以确保他们作为独立调查人员的成功。当前 高级研究员和初级教员的研究活动，他们都是 在老牌调查人员的指导下，旨在获得 对S等精神障碍性疾病根本原因的认识 儿童癌症、遗传性和获得性精神发育迟滞和唐氏症 综合征、囊性纤维化、先天性和获得性畸形 白细胞和红细胞的产生或功能，分子发病机制 微生物疾病，以及几种形式的吸收不良。支持 这笔赠款将极大地增强该部门的能力 通过以下方式提高训练有素的儿科科学家的数量和质量 使我们能够更充分地利用非凡的科学力量 和我们中心的资源；这样做将有助于满足关键的 孩子们的需要。