ADVANCING CHILD HEALTH THROUGH CELL/MOLECULAR BIOLOGY

通过细胞/分子生物学促进儿童健康

• 批准号: 3103146
• 负责人: ROBERT P KELCH
• 金额: $ 25.4万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103146
• 关键词: Downs syndrome; biomedical facility; child (0-11); computer assisted sequence analysis; computer program /software; cystic fibrosis; health science research; malabsorption; mental retardation; microscopy; molecular biology; nucleic acid sequence; pediatric neoplasm /cancer; polymerase chain reaction; scintillation counter; training; ultracentrifugation; university

Advancing Child Health Through Cell/Molecular Biology is the overall theme of the University of Michigan's Child Health Research Center. The goal of the UM CHRC is to increase the number and effectiveness of pediatric scientists through an interdepartmental approach which will provide superb mentorship by well-established cell/molecular biologists located in basic science and clinical departments as well as within the Howard Hughes Medical Institute, an extensive array of core laboratory facilities and services, and ongoing institutional and departmental commitments. The Department of Pediatrics has a long tradition of excellence in research and in the training of academic pediatricians. During the last 20 years and especially during the last decade, the department expanded the scope of its research interests, activities, and accomplishments to a remarkable degree. The department decided to build upon its strong programs in clinical physiology and to play a major role in the medical school's plan to further develop research programs in clinically relevant areas of cell and molecular biology. The rationale underlying this commitment is the firm belief that major advances in the therapy and prevention of most congenital and acquired disorders of childhood will only be possible when cellular and molecular etiologies are known. To meet our objective a large cohort of senior and junior investigators have been recruited and/or trained, scientifically-oriented fellowship training guidelines and programs have been developed and adhered to, extensive intra- and interdepartmental collaborative efforts have been fostered, and significant resources have been committed to allow for the needed expansion of physical and human resources. Moreover, the necessary administrative systems and mentorship have been established to provide additional training and guidance of junior faculty to ensure their success as independent investigators. Current research activities of senior fellows and junior faculty, all of whom are under the guidance of established investigators, are aimed toward acquiring an understanding of the basic cause(s) of such troubling disorders as childhood cancer, genetic and acquired forms of mental retardation and Down syndrome, cystic fibrosis, congenital and acquired abnormalities in the production or function of white and red blood cells, molecular pathogenesis of microbial diseases, and several forms of malabsorption. Support provided by this grant will significantly amplify the department's ability to increase the number and quality of well trained pediatric scientists by allowing us to more thoroughly utilize the remarkable scientific strengths and resources of our center; and in so doing, it will help meet a crucial need of children.

通过细胞/分子生物学促进儿童健康是总主题 密歇根大学儿童健康研究中心的研究人员。 目标是 UM CHRC 的目标是增加儿科治疗的数量和有效性 科学家们通过跨部门的方法，将提供卓越的 由位于基础领域的知名细胞/分子生物学家提供指导 科学和临床部门以及霍华德休斯内部 医学研究所，拥有广泛的核心实验室设施和 服务以及持续的机构和部门承诺。 这 儿科在研究和治疗方面有着悠久的卓越传统 在学术儿科医生的培训中。 在过去的 20 年和 特别是在过去十年中，该部门扩大了其范围 研究兴趣、活动和成就达到了显着的程度。 该部门决定以其强大的临床项目为基础 生理学并在医学院进一步发展的计划中发挥重要作用 开发细胞和临床相关领域的研究计划 分子生物学。 这一承诺的基本原理是坚定 相信大多数先天性疾病的治疗和预防方面取得了重大进展 只有当细胞和 分子病因学是已知的。 为了实现我们的目标，一大群人 已招募和/或培训高级和初级调查员， 以科学为导向的研究金培训指南和方案 已制定并遵守，广泛的部门内和跨部门 促进了协作努力，并投入了大量资源 致力于允许物质和人力的必要扩展 资源。 此外，必要的行政系统和指导 已成立，为初级人员提供额外的培训和指导 教师确保他们作为独立研究者的成功。 当前的 高级研究员和初级教师的研究活动，他们都是 在既定调查人员的指导下，旨在获取 了解此类令人不安的疾病的基本原因，例如 儿童癌症、遗传性和后天性智力低下和唐氏综合症 综合征、囊性纤维化、先天性和后天性异常 白细胞和红细胞的产生或功能，分子发病机制 微生物疾病和几种形式的吸收不良。 支持 这笔赠款提供的资金将显着增强该部门的能力 增加训练有素的儿科科学家的数量和质量 使我们能够更充分地利用卓越的科学优势 以及我们中心的资源；这样做，将有助于满足一个关键的 孩子的需要。