CENTER FOR RESEARCH ON FERTILITY AND INFERTILITY

这份P-30中心核心补助金申请是 十名教员在过去十年中发展起来的研究需求 在西北大学从事生殖研究的 生育和不孕不育的领域。这十名调查人员 目前拥有21项由NIH/NIMH资助的研究资助/项目，这些项目将 获取5个科学核心；其中12个赠款/项目由 NICHD。P-30中心核心补助金将服务的研究项目 包括对生殖神经内分泌学的研究， 性腺功能的调节机制，性腺功能的调节机制 配子发生，卵泡选择的机制，，机制 生殖激素的作用，调节生殖器的机制 追踪功能和调节生育的免疫机制。 拟议中的P-30中心核心拨款的调查人员目前 在生化会议上回答生殖科学中的问题， 分子、细胞、生理和行为水平。复杂性 今天在生殖研究领域的生命科学需要 共享技术和方法，这些技术和方法在 一个单独的研究实验室。事实上，很明显，少校 我们对生殖系统的理解的突破将 需要具有以下专业知识的研究人员的协作努力 不同的研究领域。因此，这笔赠款旨在建立五个 科学核心将使核心调查人员能够将 在他们的研究计划中加入了高度复杂的技术 具有成本效益的方式。此外，这些核心将提供高质量 在许多不同技术方面的控制和技术专长，请访问 这一水平通常不适用于个别调查人员。五人组 科学核心将作为P-30核心中心赠款的一部分建立 是西北大学调查人员确定的 最大的需求，这将对质量产生最大的影响 这所大学的生殖研究。待建立的核心 是分子技术、蛋白质分析、原位分析 杂交、单抗-细胞培养、激素和 神经递质测量。管理核心也将是 为管理中心奖助金而设立。这个项目的建立 P-30中心核心赠款将提高质量和成本效益 现有的联邦政府资助的生殖研究项目 科学，预计将导致更好地理解 生育和不育背后的调控机制。

This P-30 Center Core Grant application is a direct outgrowth of the research needs that have developed over the past decade of ten faculty at Northwestern University who are engaged in reproductive research in the areas of fertility and infertility. These ten investigators currently hold 21 funded NIH/NIMH research grants/projects that will access 5 scientific cores; 12 of these grants/projects are funded by the NICHD. The research programs to be served by the P-30 Center Core Grant include investigations into the neuroendocrinology of reproduction, the regulatory mechanisms of gonadal functions, the regulatory mechanisms of gametogenesis, the mechanisms of follicular selection, the ,mechanisms of action of reproductive hormones, the mechanisms regulating genital track functions and he immunological mechanisms regulating fertility. Investigators in the proposed P-30 Center Core Grant are currently addressing questions in the reproductive sciences at the biochemical, molecular, cellular, physiological and behavioral levels. The complexity of the life sciences in the area of reproductive research today requires the sharing of techniques and approaches that are often not available in a single research laboratory. Indeed, it is clear that major breakthroughs in our understanding of the reproductive system will require collaborative efforts of researchers who have expertise in diverse areas of research. Thus, this grant seeks to establish five scientific Cores which will enable Core investigators to incorporate highly sophisticated techniques into their research programs in a cost-effective manner. Furthermore, the Cores will provide quality control and technical expertise in a number of different techniques at a level normally not available to individual Investigators. The five scientific Cores to be established as part of the P-30 Core Center Grant were those that Northwestern investigators determined were in the greatest need and that would have the greatest impact on the quality of reproductive research at this University. The Cores to be established are those for Molecular Technology, Protein Analysis, In situ Hybridization, Monoclonal Antibody-Cell Culture, and Hormone and Neurotransmitter Measurements. An Administrative Core will also be established to administer the Center Grant. The establishment of this P-30 Center Core Grant will enhance the quality and cost-effectiveness of existing federally-funded research programs in the reproductive sciences, and is anticipated to lead to a better understanding of the regulatory mechanisms underlying fertility and infertility.