PILOT STUDY--INDUCTION OF VIRAL ACUTE HEPATITIS BY HEPATITIS B VIRUS GENES

中试研究--乙型肝炎病毒基因诱导病毒性急性肝炎

• 批准号: 3776365
• 负责人: ALEEM SIDDIQUI
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3776365
• 关键词: Hepatovirus; biomedical facility; genetic regulation; hepatitis B; liver; molecular pathology; virus DNA; virus RNA; virus genetics

Human hepatitis B virus (HBV) belongs to a family of hepadnaviruses which replicate via the reverse transcription of an RNA intermediate, the pregenome. HBV infection represents a major worldwide human health problem. It causes acute, chronic hepatitis and the infection has been linked with hepatocellular carcinoma (HCC) in humans. An understanding of the biology of HBV has been severely limited due to its narrow host range and the inability to propagate in in vitro. The earliest consequence of HBV infection is the occurrence of acute phase of viral hepatitis B. This results in elevated levels of liver enzymes. In this study, our basic inquiry relates to whether HBV X gene product is responsible for the transcriptional activation of acute phase genes of the liver. Studies are proposed here to investigate in detail the mechanism of acute viral hepatitis resulting from HBV infections. In this pilot feasibility project we propose to study the acute-phase of viral hepatitis by investigating the role HBV genes, with particular emphasis on X gene product in the transcriptional activation of acute-phase genes in the liver.

人B肝炎病毒（HBV）属于嗜肝DNA病毒家族， 通过RNA中间体的逆转录复制， 前基因组 HBV感染是全球范围内人类健康的主要问题 问题. 它会引起急性、慢性肝炎， 与人类肝细胞癌（HCC）有关。 了解 HBV的生物学特性由于其狭窄的宿主范围而受到严重限制 以及不能在体外繁殖。 最早的结果是 HBV感染是B型病毒性肝炎发生的急性期。 这 导致肝酶水平升高 在这项研究中，我们的基本 询问是否HBV X基因产物负责 肝脏急性期基因的转录激活。 研究是 本文拟详细探讨急性病毒性心肌炎的发病机制， 乙型肝炎病毒感染引起的肝炎。 在这个可行性试验项目中，我们建议研究 通过研究HBV基因的作用，特别是 强调X基因产物在转录激活的急性期 肝脏中的基因