SCOR-LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

婴儿和儿童的 SCOR-肺生物学和疾病

• 批准号: 3106902
• 负责人: PHILIP M FARRELL
• 金额: $ 71.97万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106902
• 关键词: bronchopulmonary dysplasia; child (0-11); human subject; premature infant human; respiratory distress syndrome of newborn

The UW-Madison Specialized Center of Research on "Lung Biology and Disease in Infants and Children" will be devoted to elucidation of the pathobiology of bronchopulmonary dysplasia (BPD), particularly the delineation of cellular and biochemical mechanisms potentially important in either the pathogenesis of neonatal lung injury or the repair processes that facilitate recovery from chronic respiratory insufficiency of infants. This mission will be addressed in a multidisciplinary research program featuring a combination of interrelated basic and clinical investigations designed to expedite the development and application of new knowledge that might improve our understanding and treatment of bronchopulmonary dysplasia. There will be four research projects entitled: 1. Assessment of the role of oxyradicals in the pathogenesis of BPD. 2. Retinol function in the pathogenesis and repair of BPD. 3. Calcium-dependent phospholipid-binding proteins as related to lung development, RDS, and BPD. 4. Effect of hyperoxia on alveolar type II cell proliferation and differentiation during neonatal lung growth. These investigation, will be facilitated by three core units providing: a) administrative services; b) biostatistics/computing resources and assistance; and c) research coordinating support.

威斯康星大学麦迪逊分校“肺生物学与疾病”专业研究中心 将致力于阐明病原生物学 对支气管肺发育不良(BPD)的诊断，特别是对 细胞和生化机制可能在以下两个方面发挥重要作用 新生儿肺损伤的发病机制或修复过程 促进婴儿慢性呼吸功能不全的康复。 这项任务将在一个多学科研究计划中加以解决。 具有相互关联的基础和临床研究相结合的特点 旨在加快新知识的开发和应用， 可能会提高我们对支气管肺病的认识和治疗 发育不良。将有四个研究项目，题为： 1.氧自由基在BPD发病机制中的作用 2.视黄醇在BPD发病和修复中的作用 3.与肺相关的钙依赖磷脂结合蛋白 开发、RDS和BPD。 4.高氧对肺泡II型细胞增殖的影响 新生儿肺发育过程中的分化。 这些调查将由三个核心单位提供协助，包括：a) 行政事务；b)生物统计/计算资源和 援助；以及c)研究协调支助。