A CONTROLLED TRIAL OF PHOTOTHERAPY IN RAPID-CYCLING BIPOLAR DISORDER

快速循环双相情感障碍的光疗对照试验

• 批准号: 3781527
• 负责人: ELLEN LEIBENLUFT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3781527
• 关键词: bipolar depression; bipolar depression depressed phase; blood chemistry; circadian rhythms; clinical trials; human subject; human therapy evaluation; melatonin; mood disorders; phototherapy; sleep disorders

Patients with rapid cycling bipolar experience at least four episodes of affective illness (depression, hypomania, and/or mania) in a year. They suffer significant morbidity and are frequently resistant to conventional treatments. These patients experience dramatic shifts in their sleep-wake cycle as their mood state changes. Furthermore, results from another study (Z01 MH 02614-01 CP) show consistent differences in their circadian rhythms in the depressed and hypomanic states. Since treatment with bright lights (phototherapy) has been shown to shift circadian rhythms in humans, we are conducting a controlled trial of phototherapy in patients with rapid cycling bipolar disorder to see if bright light can be used to shift their circadian rhythms and alleviate the depressive symptoms that they experience. Throughout the study, patients remain on a stable regimen of psychotropic medication. They are followed through several depressive episodes in order to establish the baseline pattern of their illness. two consecutive depressive episodes are then treated with phototherapy (one hour of 10,000 lux). Patients are randomly assigned to treatment in either the morning or evening, and then crossed over to the other condition during the second episode. Mood is monitored through daily self-ratings and weekly observer ratings. Ten days after beginning each of the phototherapy conditions, patients are admitted to the hospital for an evening in order to undergo a DLMO (dim light melatonin onset) procedure. During this procedure, patients are kept in a dimly lit room while blood samples rare withdrawn to measure the onset of melatonin secretion. The purpose of the DLMO is to determine whether the phototherapy has, as predicted, shifted the patients' circadian rhythms.

快速循环双相患者至少经历四次发作， 情感性疾病（抑郁症，轻躁狂症和/或躁狂症）。 他们 并经常对常规抗结核药物有抵抗力 治疗。 这些病人在睡眠-觉醒中经历了戏剧性的转变 随着情绪状态的变化而变化。 此外，另一项研究的结果显示， (Z01 MH 02614-01 CP）的昼夜节律表现出一致的差异 处于抑郁和轻度躁狂状态 因为用强光治疗 （光疗）已被证明可以改变人类的昼夜节律，我们是 在快速反应的患者中进行光疗的对照试验 骑自行车的双相情感障碍，看看明亮的光线是否可以用来改变他们的 昼夜节律并缓解他们的抑郁症状 体验. 在整个研究过程中，患者保持稳定的精神药物治疗方案， 药 他们会经历几次抑郁发作， 来建立他们疾病的基本模式。 连续两 抑郁发作，然后用光疗（1小时的10000 lux）。 患者被随机分配到早晨或 晚上，然后在第二次穿越到另一个条件 插曲。 通过每日自我评分和每周观察员监测情绪 评级. 在开始每种光疗条件后10天， 病人被允许在医院住一晚， DLMO（暗光褪黑激素发作）程序。 在这个过程中， 病人被关在光线昏暗的房间里，血液样本很少被抽取， 测量褪黑激素分泌的开始。 DLMO的目的是 确定光疗是否如预测的那样改变了患者的 昼夜节律