MEDICAL COLLEGE OF VIRGINIA EPILEPSY RESEARCH CENTER

弗吉尼亚医学院癫痫研究中心

• 批准号: 3100195
• 负责人: ROBERT John DELORENZO
• 金额: $ 107.05万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3100195
• 关键词: epilepsy; human subject; nervous system disorder epidemiology

The main objective of the Epilepsy Research Center (ERC) at the Medical College of Virginia is to establish an integrated and focused research program to improve health care for individuals with epilepsy and to investigate clinical and basic biological mechanisms regulating neuronal excitability and the pathogenesis of seizure disorders. The ERC has developed a consortium of five Jacob Javits Scholars and 28 experienced scientists from diverse disciplines to develop a collaborative program to study the clinical and experimental aspects of epilepsy. A major effort of this integrated research program is directed at studying the pathophysiology of status epilepticus. A unique and rigorously validated status epilepticus data base has been established in the Greater Richmond Metropolitan Area and serves as sa valuable resource for studying mortality, outcome predictors, and serves as a valuable resource for studying mortality, outcome predictors and clinical parameters of this major neurological conditions. Both animal and human studies will investigate the role of microvascular changes and superoxide formation in the pathogenesis of prolonged convulsions. Studies will also probe the role of calcium and a specific anticonvulsant binding protein in the regulation of neuronal excitability and modulation of sustained neuronal discharge. Genetic studies will investigate the genetic basis of some forms of seizures by utilizing one of the largest twin registries in the world. The research projects in the Epilepsy Research Center will test specific hypotheses developed to investigate basic mechanisms and clinical aspects of epilepsy. The component projects will investigate: 1) demographics and epidemiology of status epilepticus; 2) mortality of status epilepticus; 3) microvascular changes and superoxide formation in the pathogenesis of prolonged convulsions; 4) the role of a specific anticonvulsant binding protein in regulating neuronal excitability; 5) calcium modulation of neuronal excitability and seizure discharge; and 6) genetic basis of seizures in twins. The ERC has a clear focus of integrated research projects to understand the clinical and fundamental basis of altered neuronal excitability and seizure discharge and ultimately to develop strategies to improve the diagnosis and treatment of epilepsy.

癫痫研究中心（ERC）的主要目标是 弗吉尼亚医学院是建立一个综合和 重点研究计划，以改善个人的医疗保健 癫痫的临床和基础生物学研究 调节神经元兴奋性的机制和发病机制 癫痫的症状 ERC已经建立了一个由五个 Jacob Javits学者和28位经验丰富的科学家， 学科，以制定一个合作计划，研究 癫痫的临床和实验方面。 一项重大努力， 该综合研究计划旨在研究 癫痫持续状态的病理生理学 一个独特而严格的 已在 大里士满都会区，并作为一个有价值的 研究死亡率、结局预测因素的资源， 作为研究死亡率、结局、 这一主要神经系统疾病的预测因子和临床参数 条件 动物和人类研究都将调查 微血管变化和超氧化物形成在 长期惊厥的发病机制。 研究还将探讨 钙和一种特异性抗惊厥剂结合蛋白在 神经元兴奋性的调节和持续性的调节 神经元放电 遗传学研究将调查遗传 利用世界上最大的 双胞胎登记处 癫痫研究中心的研究项目将测试 为研究基本机制而提出的具体假设， 癫痫的临床表现 各组成项目将 调查：1）人口统计学和流行病学现状 癫痫持续状态; 2）癫痫持续状态的死亡率; 3）微血管 在慢性乙型肝炎发病机制中的变化和超氧化物的形成 惊厥; 4）特定抗惊厥剂结合的作用 调节神经元兴奋性的蛋白质; 5）钙调节 神经元兴奋性和癫痫放电;和6）遗传 双胞胎癫痫发作的基础 ERC有一个明确的综合研究项目的重点， 了解改变神经元的临床和基本基础 兴奋性和癫痫放电，并最终发展为 提高癫痫诊断和治疗的策略。