Cumulus cell invasive migration: clearing a path for the oocyte

卵丘细胞侵入性迁移：为卵母细胞扫清道路

• 批准号: nhmrc : 1011297
• 负责人: A/Pr Darryl Russell
• 金额: $ 27.32万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cumulus-cell-invasive-path-oocyte/109568
• 关键词: Cumulus; cell; invasive; migration; clearing

Ovulation is the process by which the egg is released from a female�s ovary, but it is not known how this process is controlled. We found that cells surrounding the egg are motile and similar to cancer cells; thus we hypothesize that this enables the egg to _invade� its way out of the ovary. We will test this idea in mice and determine whether similar processes are happening in women. The results will provide new information about how to stop ovulation and aid women who experience infertility.

排卵是卵子从女性卵巢中释放出来的过程，但这个过程是如何控制的尚不清楚。我们发现卵子周围的细胞是活动的，与癌细胞相似；因此，我们假设这使得卵子能够“入侵”出卵巢。我们将在老鼠身上测试这一想法，并确定类似的过程是否发生在女性身上。研究结果将提供关于如何停止排卵和帮助不孕妇女的新信息。