Re-energising the preimplantation embryo to extend lifetime health

为植入前胚胎重新注入能量，延长终生健康

• 批准号: nhmrc : 1130364
• 负责人: A/Pr Darryl Russell
• 金额: $ 79.03万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/re-energising-preimplantation-lifetime-health/948568
• 关键词: Re; energising; preimplantation; embryo; extend

Diseases of aging are associated with shortening at the ends of chromosomes called telomeres. The length of an individual’s telomeres is established during embryo development, and in situations where embryo development is compromised such as with maternal obesity the normal process of telomere lengthening may not occur. We will determine how such disruptions in embryo telomere lengthening contribute to poor health in adulthood and test ways to restore the natural process.

衰老疾病与染色体末端端粒的缩短有关。个体端粒的长度是在胚胎发育过程中确定的，在胚胎发育受到损害的情况下，如母亲肥胖，端粒的正常延长过程可能不会发生。我们将确定胚胎端粒延长的这种中断如何导致成年后健康状况不佳，并测试恢复自然过程的方法。