HIV IN INFANTS--EARLY IMMUNITY AND VIRAL SUSCEPTIBILITY

婴儿艾滋病毒——早期免疫力和病毒易感性

• 批准号: 3785363
• 负责人: MILES W CLOYD
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3785363
• 关键词: AIDS /HIV diagnosis; antiviral antibody; communicable disease transmission; diagnosis design /evaluation; human subject; humoral immunity; immunogenetics; pediatric AIDS; virus antigen

Addresses 2 issues currently important in Pediatric HIV infection: 1) development of an improved method to diagnose infection of newborns, and 2) determination of why only some offspring from infected mothers are HIV-infected. Tests hypotheses that HIV-infected newborns mount IgM antibody responses recognizing "native" conformational gp160 epitopes similar to those observed here in early infected adults, and that differential mother to offspring transmission of HIV involves the infant's genetic susceptibility to the mother's isolate virus.

解决目前儿童 HIV 感染中的 2 个重要问题：1) 开发诊断新生儿感染的改进方法，以及 2) 确定为什么只有部分受感染母亲的后代受到感染 感染艾滋病毒。测试感染 HIV 的新生儿会产生 IgM 的假设 识别“天然”构象 gp160 表位的抗体反应 与这里在早期感染成人中观察到的情况类似，并且 HIV 母婴传播的差异涉及 婴儿对母亲分离病毒的遗传易感性。