婴儿艾滋病毒——早期免疫力和病毒易感性-猫眼课题宝

婴儿艾滋病毒——早期免疫力和病毒易感性

批准号：

3785363

负责人：

MILES W CLOYD

金额：

$0.0万

依托单位：

UNIVERSITY OF TEXAS MED BR GALVESTON

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3785363

关键词：

AIDS /HIV diagnosis antiviral antibody communicable disease transmission diagnosis design /evaluation human subject humoral immunity immunogenetics pediatric AIDS virus antigen

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英文摘要

Addresses 2 issues currently important in Pediatric HIV infection: 1) development of an improved method to diagnose infection of newborns, and 2) determination of why only some offspring from infected mothers are HIV-infected. Tests hypotheses that HIV-infected newborns mount IgM antibody responses recognizing "native" conformational gp160 epitopes similar to those observed here in early infected adults, and that differential mother to offspring transmission of HIV involves the infant's genetic susceptibility to the mother's isolate virus.

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