STANDARDIZATION OF ALLERGENIC EXTRACTS OF POLLENS

标准化工作的重点是蒂莫西，琼，常年黑麦， 百慕大、红顶和果园草萃取精华，共21种应用 另有52件拍品正在接受审查。一家公司提交的每一份摘录 对其等电聚焦模式、IgE结合活性进行了分析 斑点放射免疫电聚焦(Brief)、总蛋白含量和 RAST相对效力与CBER参考提取物的比较。其中一些 这些产品也已提交IND进行临床测试。 为了便于花粉提取液的标准化，LAP 目前提供所有检测试剂和参考 公司。需要正在进行的检测来补充实验室用品 这些项目中的每一项。候选推荐人不断被 在实验室进行同步临床测试评估。这个 甜菊、巨人等花粉提取物的标准化 豚草和草地羊茅正在进行中，参考制剂已经 经过挑选、测试和订购，以进行下一阶段的标准化。

Standardization efforts have focused on Timothy, June, Perennial Rye, Bermuda, Redtop and Orchard grass extracts with a total of 21 applications and 52 lots now under review. Each extract submitted by a company is analyzed for its IsoElectric focusing pattern, IgE binding activity by Blotted RadioImmuno ElectroFocusing (BRIEF), total protein content, and RAST relative potency compared to CBER reference extracts. Some of these products have also been submitted for Clinical testing under IND. In order to facilitate the standardization of pollen extracts, LAP currently supplies all testing reagents and references to the companies. Ongoing testing is needed to replenish laboratory supplies for each of these items. Candidate references are constantly being evaluated in the laboratory for concurrent clinical testing. The standardization of other pollen extracts including Sweet Vernal, Giant Ragweed and Meadow Fescue are in progress, and Reference preparations have been selected, tested and ordered for the next phase of standardization.