PEDIATRIC AIDS CLINICAL TRIALS UNIT

华盛顿大学（UW）儿科ACTU教师的目标是 在门诊病人中进行示范性的艾滋病毒/艾滋病治疗研究， 作为国家多中心艾滋病临床试验组的一部分， （ACTG）。 UW儿科ACTU的具体目标是进行I期、II期和III期研究。 在这些领域的III类研究：1）原发性儿科感染; 2） 机会性感染; 3）围产期试验。 另一个目标是 开展机会性感染研究，特别是生殖器感染 感染可能导致并发症，如妇女的宫颈癌。 我们有一个包括儿科在内的调查小组， 妇产科和内科，有经验的执行 抗病毒和其他临床试验在孕妇，婴儿和 孩子 华盛顿大学是美国五州地区的转介中心。 太平洋西北地区的儿童和孕妇艾滋病毒， 随访了90名儿童和70%以上的HIV血清阳性孕妇 在这个地区。 华盛顿和俄勒冈州经历了一场 1989年至1990年，孕妇艾滋病毒血清阳性率增加40%， 而这一增长主要发生在少数民族。 总 少数民族的人数是36%的非洲裔美国人，21%的美洲原住民，3%的 西班牙裔和2%的亚裔。 我们建立了西北家庭中心 （NWFC），一个“一站式购物”设施，拥有多元文化的工作人员， 提供临床护理、社会支持和参与ACTG临床试验。 由于药物滥用是80%的人感染艾滋病毒的机制， 对于血清反应阳性的孕妇，NWFC与一个治疗方案合用同一地点， 对于化学依赖的孕妇。 我们有基础设施， 招募并留住感染艾滋病毒的孕妇及其婴儿， 作为艾滋病毒感染的儿童， 时尚. 我们将招募至少35名感染艾滋病毒的孕妇， 他们的婴儿以及28名艾滋病毒感染儿童每年在临床 审判 该提案寻求资金，以实现独立地位， 儿科ACTU和俄勒冈州子单位的建立。

The goal of the University of Washington (UW) pediatric ACTU faculty is to perform exemplary HIV/AIDS treatment research in outpatients and inpatients as part of the national multicenter AIDS Clinical Trials Group (ACTG). The UW Pediatric ACTU's specific aims are to conduct Phase I, II and III studies in these areas: 1) primary pediatric infection; 2) opportunistic infections; and 3) perinatal trials. An additional aim is conduct of studies of opportunistic infections, especially genital infections with potential complications such as cervical cancer in women. We have an established investigative team including pediatrics, obstetrics, gynecology and internal medicine, experienced in performing antiviral and other clinical trials in pregnant women, infants and children. The UW is the referral center for a five-state region of the Pacific Northwest for HIV in children and pregnant women, and has followed 90 children and over 70% of the HIV seropositive pregnant women in this region. The states of Washington and Oregon have experienced a 40% increase in HIV seroprevalence in pregnant women from 1989 to 1990, and this increase has occurred mainly in ethnic minorities. Total minority numbers are 36% African American, 21 % Native American, 3% Hispanic and 2% Asian. We have established the Northwest Family Center (NWFC), a "one-stop-shopping" facility with a multicultural staff to provide clinical care, social support and access to ACTG clinical trials. As substance abuse was the mechanism of HIV infection in 80% of seropositive pregnant women, NWFC has co-located with a treatment program for chemically dependent pregnant women. We have the infrastructure to enroll and retain HIV infected pregnant women and their infants, as well as HIV infected children, on ACTG protocols in a culturally sensitive fashion. We will enroll at least 35 HIV infected pregnant women and their infants as well as 28 HIV infected children per year in clinical trials. This proposal seeks funding to achieve independent status as a Pediatric ACTU and establishment of the Oregon Subunit.