PEDIATRIC AIDS CLINICAL TRIALS UNIT

儿科艾滋病临床试验单位

• 批准号: 3548007
• 负责人: SANDRA K BURCHETT
• 金额: $ 75.36万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3548007
• 关键词: AIDS; AIDS therapy; child (0-11); clinical trials; congenital infection; cooperative study; human immunodeficiency virus 1; human pregnant subject; human subject; human therapy evaluation; nervous system infection; opportunistic infections; pediatric AIDS; virus related neoplasm /cancer; zidovudine

The goal of the University of Washington (UW) pediatric ACTU faculty is to perform exemplary HIV/AIDS treatment research in outpatients and inpatients as part of the national multicenter AIDS Clinical Trials Group (ACTG). The UW Pediatric ACTU's specific aims are to conduct Phase I, II and III studies in these areas: 1) primary pediatric infection; 2) opportunistic infections; and 3) perinatal trials. An additional aim is conduct of studies of opportunistic infections, especially genital infections with potential complications such as cervical cancer in women. We have an established investigative team including pediatrics, obstetrics, gynecology and internal medicine, experienced in performing antiviral and other clinical trials in pregnant women, infants and children. The UW is the referral center for a five-state region of the Pacific Northwest for HIV in children and pregnant women, and has followed 90 children and over 70% of the HIV seropositive pregnant women in this region. The states of Washington and Oregon have experienced a 40% increase in HIV seroprevalence in pregnant women from 1989 to 1990, and this increase has occurred mainly in ethnic minorities. Total minority numbers are 36% African American, 21 % Native American, 3% Hispanic and 2% Asian. We have established the Northwest Family Center (NWFC), a "one-stop-shopping" facility with a multicultural staff to provide clinical care, social support and access to ACTG clinical trials. As substance abuse was the mechanism of HIV infection in 80% of seropositive pregnant women, NWFC has co-located with a treatment program for chemically dependent pregnant women. We have the infrastructure to enroll and retain HIV infected pregnant women and their infants, as well as HIV infected children, on ACTG protocols in a culturally sensitive fashion. We will enroll at least 35 HIV infected pregnant women and their infants as well as 28 HIV infected children per year in clinical trials. This proposal seeks funding to achieve independent status as a Pediatric ACTU and establishment of the Oregon Subunit.

华盛顿大学(UW)儿科ACTU教师的目标是 在门诊患者中开展模范艾滋病毒/艾滋病治疗研究，并 作为国家多中心艾滋病临床试验小组成员的住院患者 (ACTG)。华盛顿大学儿科ACTU的具体目标是进行第一阶段、第二阶段 这些领域的III项研究：1)儿科原发感染；2) 机会性感染；3)围产期试验。另一个目标是 开展机会性感染研究，特别是生殖器感染研究 有潜在并发症的感染，如妇女的宫颈癌。 我们有一支成熟的调查团队，包括儿科， 产科、妇科和内科，有表演经验 抗病毒和其他临床试验在孕妇、婴儿和 孩子们。威斯康星大学是美国五个州地区的咨询中心。 太平洋西北地区儿童和孕妇的艾滋病毒，并已 跟踪调查了90名儿童和超过70%的艾滋病毒血清阳性孕妇 在这个地区。华盛顿州和俄勒冈州经历了一场 从1989年到1990年，孕妇的艾滋病毒血清阳性率增加了40%， 而这一增长主要发生在少数民族。总计 少数民族占36%非裔美国人，21%土著美国人，3% 西班牙裔和2%的亚洲人。我们成立了西北家庭中心 (NWFC)，一个拥有多元文化员工的一站式购物设施 提供临床护理、社会支持和参加ACTG临床试验。 由于药物滥用是80%的人感染艾滋病毒的机制 血清阳性孕妇，NWFC已与一项治疗计划共处一地 适用于化学依赖型孕妇。我们有基础设施来 登记和保留感染艾滋病毒的孕妇及其婴儿 作为感染艾滋病毒的儿童，对ACTG方案在文化上具有敏感性 时尚。我们将招收至少35名感染艾滋病毒的孕妇和 他们的婴儿以及每年在临床上感染艾滋病毒的28名儿童 审判。这项提案寻求资金，以实现独立的 儿科ACTU和俄勒冈亚单位的建立。