THE SYNTHESIS OF OLIGONUCLEOTIDES VIA THE PHOSPHORAMIDITE APPROACH

通过亚磷酰胺方法合成寡核苷酸

• 批准号: 3792433
• 负责人: S L BEAUCAGE
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3792433
• 关键词: amides; nucleic acid chemical synthesis; oligonucleotides; technology /technique

The P.I. has completed the second of two comprehensive reviews pertaining to the synthesis of oligonucleotides by the phorphoramidite approach and the synthetic application of phosphoramidite derivatives. The first review has appeared in Tetrahedron in March 1992 and has attracted considerable attention. More than 130 reprints have been sent to requestors within two months of the publication date. The second review is currently being checked for references accuracy and typographical mistakes. The updated manuscript contains more than 600 references and has already been accepted for publication in Tetrahedron. The review will be submitted to the editor by August 1992. It must be noted that these review articles are relevant to the P.I.'s research program and expertise. The P.I. has recently revised a book chapter about the synthesis of oligonucleotides by the phosphoramidite approach. The editor has informed the P.I. that the book will appear in January 1993. The editor of Organic Preparations and Procedures International (Dr. J. P. Anselme) has invited the P.I. to write a review about sulfur-transfer reagents. The P.I. may or may not accept this commission depending on the progress of the current research projects underway in the laboratory.

私家侦探已完成两项全面检讨中的第二项 关于通过亚磷酰胺合成寡核苷酸， 方法及亚磷酰胺衍生物的合成应用。 第一篇评论发表在1992年3月的《四面体》上， 引起了相当大的关注。 已发送130多份再版 在出版日期后两个月内向申请人提供。 目前正在检查第二次审查的参考资料准确性， 印刷错误 更新后的手稿包含600多个 参考文献，并已被接受发表在四面体。 评论将于1992年8月提交编辑。 必须 注意到这些综述文章与P.I.相关。的调研 计划和专业知识。 私家侦探最近修订了一本书的一章， 通过亚磷酰胺方法制备寡核苷酸。 编辑已 告诉了私家侦探该书将于1993年1月出版。 《有机制备和程序国际》（Organic Preparations and Procedures International）的编辑J. P.安塞尔姆）邀请了私家侦探。写一篇关于硫转移的评论 试剂 私家侦探可能会或可能不会接受此佣金取决于 目前在香港进行的研究项目的进展， 实验室