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STABILIZATION OF POLIOVIRUS INFECTIVITY TO LYOPHILIZATION

STABILIZATION OF POLIOVIRUS INFECTIVITY TO LYOPHILIZATION
冻干脊髓灰质炎病毒感染性的稳定
批准号:
3792549
负责人:
R E LUNDQUIST
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
如果不这样做,口服脊髓灰质炎病毒疫苗(OPV)可迅速失去效力
英文摘要
Oral poliovirus vaccine (OPV) can rapidly lose potency when not maintained in a frozen state. Stabilization of OPV to less stringent storage conditions would greatly facilitate the poliovirus immunization program. Some vaccines can be lyophilized and stored in a solid state, but poliovirus infectivity is greatly diminished after lyophilization. We have systematically evaluated different conditions and additives in search of a procedure that would allow the successful lyophilization of poliovirus. Lyophilized material was assayed by both the Elisa assay for D antigen and for infectious virus by a plaque assay. Dramative improvements in viral survival were obtained with the use of a lipid based reagent, which increased viral survival by 1000 and resulted in 20-40% of the viral infectivity surviving lyophilization. Attempts are continuing to further increase virus stability to lyophilization and to evaluate the temporal and temperature stability of the lyophilized virus.
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  • 批准号:
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  • 项目类别:
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  • 财政年份:
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  • 项目类别:
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    $0.0万
  • 财政年份:
    --
  • 负责人:
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  • 依托单位:
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  • 批准号:
    6547096
  • 项目类别:
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  • 财政年份:
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  • 批准号:
    3770310
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
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  • 依托单位:
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