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STANDARDS FOR ASSAY OF VON WILLEBRAND FACTOR--A COLLABORATIVE STUDY

STANDARDS FOR ASSAY OF VON WILLEBRAND FACTOR--A COLLABORATIVE STUDY
血管性血友病因子测定标准--一项合作研究
批准号:
3792652
负责人:
M A LAMB
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
一项多实验室合作研究进行了评估
英文摘要
A multilaboratory collaborative study was undertaken to assess the feasibility of using a plasma standard for assaying the von Willebrand factor content of von Willebrand factor concentrates and of factor VIII concentrates. Thirteen laboratories tested six concentrates for von Willebrand factor antigen, ristocetin cofactor activity, and multimer content using the World Health Organization plasma standard for factor VIII/von Willebrand factor, 87/718, as a standard. Only a few assays were invalid because of nonparallelism or nonlinearity. Significant interlaboratory and interassay differences were found for both von Willebrand factor antigen and ristocetin cofactor activity. There was generally good agreement between the laboratories with respect to multimer content in the preparations. With respect to assay validity, a plasma standard could be suitable for assaying concentrated preparations of von Willebrand factor.
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会议论文
COAGULATION FACTOR IX STANDARDIZATION STUDY
VON WILLEBRAND FACTOR STANDARDIZATION STUDY
MOLECULAR INTEGRITY OF FVIII IN COMMERCIAL FVIII CONCENTRATES
国内基金
海外基金
ITS-HPLC-HRMS-Bioassay多级筛选策略指导下海洋真菌中新型抗菌活性产物的发现