PEDIATRIC ONCOLOGY GROUP STUDIES

拟议研究的总体目标是继续努力实现 确定对所有类型癌症儿童的最佳护理。这个 研究机制涉及儿科研究人员在 多学科协作中的鲍曼·格雷医学院 儿科肿瘤学小组的临床肿瘤学方案以及 继续与北卡罗来纳州和南卡罗来纳州的其他中心合作。 拟议的研究补助金将允许以下人员继续参与 鲍曼·格雷医学院作为儿科协会的正式成员 肿瘤学集团，并将为我们的附属机构在 南卡罗来纳州格林维尔。作为我们不断扩张的自然产物 计划和活动，这笔赠款将规定直接独立 资助鲍曼·格雷医学院(前身为 杜克大学附属公司)。 我们在过去几年中取得的成就在 格兰特提案。我们今年五年的体制目标 资助金包括：(1)延续我们不断增加的应计利润纪录和我们的 对POG做出了卓越的临床贡献，包括我们100%的记录 患者可评估性和协议遵从性；(2)扩展我们的 机构参与POG白血病的设计和开发 研究；(3)进一步发展我们对大脑的兴趣 肿瘤和我们的神经肿瘤诊所，导致患者增加 脑肿瘤方案的登记和POG中的研究人员角色 脑瘤委员会；(4)继续大力参与POG 霍奇金氏病活动性；(5)后遗症的增加 研究并积极参与POG后效委员会；(6) 我们在POG细胞遗传学委员会中的作用显著扩大 第二个POG细胞遗传学参考实验室的开发 鲍曼·格雷；(7)继续为行政管理做出重大贡献 POG的各个方面，目前我们在 行政和机构业绩审查委员会。 最后，我们计划继续与我们的 位于南卡罗来纳州格林维尔的附属机构，目标是确保最佳 为我们转诊区域内所有癌症儿童提供临床护理。

The overall goal of the proposed research is to continue to work towards determining the optimum care for children with all types of cancer. The research mechanism involves participation by pediatric investigators at the Bowman Gray School of Medicine in collaborative multidisciplinary clinical oncology protocols of the Pediatric Oncology Group as well as continued collaboration with other centers in North and South Carolina. The proposed research grant will allow for the continued participation of the Bowman Gray School of Medicine as a full member of the Pediatric Oncology Group and will provide support for our affiliate institution in Greenville, South Carolina. As a natural outgrowth of our expanding program and activities, this grant will provide for direct independent funding of the Bowman Gray School of Medicine (formerly funded as an affiliate of Duke University). Our accomplishments in the past years are described in detail in the grant proposal. Our institutional goals for the five year period of this grant include: (1) continuing our record of increasing accrual and our excellent clinical contribution to the POG, including our record of 100% patient evaluability and protocol compliance; (2) expanding our institutional involvement in the design and development of POG leukemia studies; (3) further institutional development of our interest in brain tumors and our neuro-oncology clinic, leading to increasing patient enrollment on brain tumor protocols and to investigator roles in the POG Brain Tumor Committee; (4) continuation of our strong involvement in POG Hodgkin's disease activities; (5) increasing development of late effects studies and active participation with the POG Late Effects Committee; (6) significant expansion of our role in the POG Cytogenetics Committee and the development of a second POG Cytogenetics Reference Laboratory at Bowman Gray; (7) continued major contributions to the administrative aspects of the POG, as presently exemplified by our roles on the Executive and Institutional Performance Review Committees. Finally, we plan to continue our very close working relationship with our affiliate institution in Greenville, SC with the goal of assuring optimal clinical care for all children with cancer in our referral area.