Deadly commute - targeting the trafficking mechanisms that licence inflammatory cell death

致命的通勤——针对导致炎症细胞死亡的贩运机制

• 批准号: nhmrc : 2002965
• 金额: $ 77.45万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deadly-commute-targeting-cell-death/1780050
• 关键词: Deadly; commute; targeting; trafficking; mechanisms

MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.

MLKL是一种天然存在于细胞内的蛋白质。MLKL由炎症激活。一旦激活，MLKL就会重新定位到细胞的外周，并杀死它们。肠道细胞特别容易被MLKL致死，这一问题会导致炎症性肠病。使用尖端显微镜，我们已经发现MLKL在杀死细胞之前是如何移动到细胞外围的。我们将测试阻止MLKL向细胞外围移动是否能阻止肠道死亡和炎症性肠病。