Deadly commute - targeting the trafficking mechanisms that licence inflammatory cell death

MLKL是一种天然存在于细胞内的蛋白质。MLKL被炎症激活。一旦被激活，MLKL就会重新定位到细胞的外周并杀死它们。肠细胞特别容易因MLKL而死亡，这个问题会导致炎症性肠病。使用尖端显微镜，我们已经发现MLKL如何在杀死细胞之前移动到细胞的外围。我们将测试阻断MLKL向细胞外周的这种运动是否会阻止肠道死亡和炎症性肠病。

MLKL is a protein naturally found inside cells. MLKL is activated by inflammation. Once activated, MLKL relocates to the outer periphery of cells and kills them. Gut cells are especially vulnerable to death-by-MLKL and this problem causes Inflammatory Bowel Disease. Using cutting edge microscopy, we have discovered how MLKL moves to the periphery of cells prior to killing them. We will test if blocking this movement of MLKL to the cell periphery stops gut death and Inflammatory Bowel Disease.