DRUG SELF-ADMINISTRATION--ENVIRONMENTAL & PHARMACOLOGICAL DETERMINANTS

自我给药——环境

• 批准号: 3874843
• 负责人: WILLIAM L WOOLVERTON
• 金额: --
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874843
• 关键词: Macaca mulatta; cocaine; discrimination learning; dosage; drug addiction; drug administration rate /duration; food; injection /infusion; intravenous drug abuse; methamphetamine; preference; procaine; psychological reinforcement; psychopharmacology; reinforcer; saline; self medication; self stimulation

Drug self-administration, like other learned behaviors, is acquired, maintained and can be extinguished and reinitiated. Environmental (e.g., schedule of reinforcement), pharmacological (e.g., drug dose) and organismal variables can influence drug-maintained behaviors. The purpose of the research in the present proposal is to use an animal model of drug abuse to investigate how environmental and pharmacological variables can affect maintenance and reinitiation of drug taking as well as behaviors generated by schedules of drug self-administration. Three series of experiments are proposed. The purpose of the first series is to examine the effect of manipulating several environmental variables on drug self-administration. Monkeys will be trained in a discrete-trials choice procedure to choose between a drug injection and a non-drug reinforcer, food. The effect of environmental variables such as schedule of reinforcement and punishment on the frequency of drug choice will be determined. The purpose of the second series is to examine variables that influence the probability that extinguished drug self-administration will be reinstated. Monkeys will be allowed to self-administer drug or saline and the ability of pre-session drug injections to reinstate responding for saline will serve as a model for relapse. The effect by environmental (e.g., schedule of reinforcement) and pharmacological (e.g., drug that maintains behavior) on the probability that a drug injection will reinstate the self-administration response will be examined. The third series is designed to pursue the finding that certain schedules of drug self-administration can generate excessive behavior that is not directly related to the drug injection. It is likely that the behavior can be classified as an adjunctive behavior. Experiments are proposed that will further examine the similarities between this and other adjunctive behaviors by examining conditions of drug availability that generate excessive behavior. In addition, modification of the behavior by environmental and pharmacological consequences will be examined. Taken together, these experiments will expand our knowledge of the variables that control acquisition, maintenance and reinitiation of drug self-administration. In addition, we will begin to explore other behavioral concomitants of drug self-administration. The results will have important implications for our understanding of the variables that control, as well as the behavioral complexity of, drug abuse in humans.

药物的自我管理，就像其他习得的行为一样，是后天获得的， 保持并可以熄灭和重新启动。环境（例如， 强化时间表）、药理学（例如药物剂量）和 有机变量可以影响药物维持的行为。目的 本提案中的研究重点是使用药物动物模型 滥用以调查环境和药理变量如何影响 影响药物服用的维持和重新开始以及行为 由药物自我给药时间表产生。 提出了三个系列的实验。第一个系列的目的 是为了检查操纵几个环境变量对 药物自我管理。猴子将接受离散试验的训练 选择程序 在药物注射和非药物注射之间进行选择 强化剂, 食物.环境变量（例如时间表）的影响 对药物选择频率的强化和惩罚将 决定。 第二个系列的目的是检查影响 已终止的自我给药恢复的可能性。 猴子将被允许自行施用药物或盐水，并且有能力 会前注射药物以恢复对生理盐水的反应 作为复发的模型。环境的影响（例如，时间表 强化）和药理学（例如维持行为的药物） 药物注射恢复的可能性 将检查自我管理反应。 第三系列旨在追求某些时间表的发现 自我给药可能会产生过度行为，而这种行为不属于 与药物注射直接相关。该行为很可能会 被归类为辅助行为。建议进行实验 进一步检查这个和其他形容词之间的相似之处 通过检查产生的药物可用性条件来进行行为 过度的行为。此外，通过改变行为 将检查环境和药理学后果。 总而言之，这些实验将扩展我们的知识 控制药物获取、维持和重新开始的变量 自我管理。此外，我们将开始探索其他行为 药物自我给药的伴随物。结果将具有重要意义 对我们理解控制变量的影响 由于人类滥用药物的行为复杂性。