THE PROTECTIVITY OF AN ANTI-SUBTYPE ANTIBODY AGAINST HBV INFECTION

乙肝表面抗原(HBs)由一组特异性的 行列式、a和至少两个子类型系统，d/y和w/r。d/y和 W/R特性以等位方式表现，并且它们代表 不同基因类型的乙肝病毒的表达。 到目前为止，对乙肝病毒感染的保护一直被归因于 针对共同组决定簇a的抗体。 抗亚型抗体的保护性尚未得到评估。这个 对决定簇d的单抗的可用性进行了评估。 有可能。一只黑猩猩被静脉接种了标准的乙肝病毒 预先孵化的接种物(ADW亚型，10,000 CID-50) 比单抗高出225倍。接种后， 黑猩猩在一段时间内没有表现出任何乙肝病毒感染的血清学标志 为期44周。在那段时间结束的时候，黑猩猩 用标准的接种剂进行挑战，发现是敏感的。因此， 用该单抗实现了中和。

The hepatitis B surface antigen (HBsAg) consists of a group-specific determinant, a, and at least two subtype systems, d/y and w/r. The d/y and w/r specificities behave in an allelic manner and they represent the expression of distinct genotypes of HBV. Heretofore, protection against HBV infection has been ascribed to antibodies directed toward the common group determinant, a. Protectivity by the anti-subtype antibodies has not been assessed. The availability of monoclonal antibody to determinant, d, made this evaluation possible. A chimpanzee was intravenously inoculated with the standard HBV inoculum (adw subtype, 10,000 CID-50) which had been preincubated with 225-fold excess of the monoclonal anti-d. After the inoculation, the chimpanzee did not express any serological markers for HBV infection for a period of 44 weeks. At the end of that period, the chimpanzee was challenged with the standard inoculum and found to be susceptible. Hence, neutralization was achieved by this monoclonal anti-d.