OBSERVATION VS. INTENSIVE CHEMOTHERAPY FOR INDOLENT LYMPHOMA

这项研究是十年前设计的，目的是比较两种药物的疗效和长期疗效。 两种截然不同的治疗方法的长期存活率 未经治疗的惰性淋巴瘤患者：观察或 延迟治疗(观察和等待)与初始强化联合治疗 使用ProMACE/MOPP柔韧疗法进行化疗以完全缓解，随后 采用加固式改良全结节照射。到目前为止还没有 无病存活率或总体存活率的显著差异， 尽管两者在完全应答率上存在差异 75%的患者随机接受强化治疗的随机组 与那些接受治疗的患者29%的CR率相比，达到完全缓解 经过一段时间的观察。中位数的随访时间为六年， 短于这些患者的中位生存期(10年) 诊断。持续的随访可能会显示出以下方面的好处 病人。

This study was designed ten years ago to compare the efficacy and the long- term survival of two very different therapeutic approaches towards previously untreated patients with indolent lymphoma: observation or delayed therapy (watch and wait) vs. initial intensive combination chemotherapy with ProMACE/MOPP flexitherapy to complete remission, followed by consolidative modified total nodal irradiation. To date there are no significant differences in disease-free survival or overall survival, although there are differences in complete response rates between the two randomized groups with 75% of patients randomized to intensive therapy achieving a complete response compared to a CR rate of 29% in those treated after a period of observation. The median follow-up time is six years, shorter than the median survival (10 years) of patients with these diagnoses. Continued follow-up may show a benefit for a subset of patients.