OBSERVATION VS. INTENSIVE CHEMOTHERAPY FOR INDOLENT LYMPHOMA

这项研究是十年前设计的，目的是比较 两种截然不同的治疗方法的长期存活率 未经治疗的惰性淋巴瘤患者：观察或 延迟治疗(观察和等待)与初始强化联合治疗 使用ProMACE/MOPP柔韧疗法进行化疗以完全缓解， 然后进行固定性改良全结节放疗。到目前为止 在无病存活率或总体上没有显著差异 存活率，尽管完全应答率存在差异 在两个随机化组之间，74%的患者随机到 强化治疗获得完全缓解，与完全缓解率相比 在观察一段时间后接受治疗的患者中有40%。中位数 随访时间为6年，短于中位生存期(10年) 有这些诊断的患者。继续随访可能会显示 使部分患者受益。

This study was designed ten years ago to compare the efficacy and the long-term survival of two very different therapeutic approaches towards previously untreated patients with indolent lymphoma: observation or delayed therapy (watch and wait) vs. initial intensive combination chemotherapy with ProMACE/MOPP flexitherapy to complete remission, followed by consolidative modified total nodal irradiation. To date there are no significant differences in disease-free survival or overall survival, although there are differences in complete response rates between the two randomized groups with 74% of patients randomized to intensive therapy achieving a complete response compared to a CR rate of 40% in those treated after a period of observation. The median follow-up time is six years, shorter than the median survival (10 years) of patients with these diagnoses. Continued follow-up may show a benefit for a subset of patients.