ROTAVIRUS VP7 NEUTRALIZATION EPITOPES OF SEROTYPE 3 STRAINS

人轮状病毒第三血清型具有中和作用 与来自猴、狗、猫的轮状病毒的特异性， 马、兔子和老鼠。 此外，该血清型的病毒 包括所有已知亚组特异性的菌株（即，一，二， 我和我都不是，我和我都不是。 少校的关系 中和蛋白，VP7的各种血清型3株， 通过测试它们与VP7单克隆抗体的反应性进行分析 （mAb）和比较核苷酸和氨基酸序列。 这 进行了分析，试图阐明抗原 为了更好地了解血清3型的进化， 轮状病毒菌株已经建立了非常广泛的 宿主范围。

The third serotype of human rotavirus shares neutralization specificity with rotaviruses derived from monkeys, dogs, cats, horses, rabbits, and mice. In addition, viruses of this serotype include strains of all known subgroup specificities (i.e., I, II, neither I nor II, both I and II). The relationships of the major neutralization protein, VP7 of the various serotype 3 strains were analyzed by testing their reactivity with VP7 monoclonal antibodies (mAbs) and by comparing nucleotide and amino acid sequence. This analysis was performed in an attempt to clarify antigenic relationships and to better understand to evolution of serotype 3 rotavirus stains which have established an extraordinarily broad host range.