ROTAVIRUS VP7 NEUTRALIZATION EPITOPES OF SEROTYPE 3 STRAINS

轮状病毒 VP7 血清型 3 株的中和表位

• 批准号: 3818279
• 负责人: K NISHIKAWA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3818279
• 关键词: Primates; Rotavirus; antibody neutralization test; cats; communicable disease transmission; dogs; epidemiology; genetic strain; horses; immunogenetics; laboratory mouse; monoclonal antibody; nucleic acid sequence; protein sequence; serotyping; virus genetics; virus morphology

The third serotype of human rotavirus shares neutralization specificity with rotaviruses derived from monkeys, dogs, cats, horses, rabbits, and mice. In addition, viruses of this serotype include strains of all known subgroup specificities (i.e., I, II, neither I nor II, both I and II). The relationships of the major neutralization protein, VP7 of the various serotype 3 strains were analyzed by testing their reactivity with VP7 monoclonal antibodies (mAbs) and by comparing nucleotide and amino acid sequence. This analysis was performed in an attempt to clarify antigenic relationships and to better understand to evolution of serotype 3 rotavirus stains which have established an extraordinarily broad host range.

第三种血清型人轮状病毒具有中和作用