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BIOLOGICAL AND BIOCHEMICAL STUDIES OF ANTIGENS ON MALARIA-INFECTED RED CELLS

BIOLOGICAL AND BIOCHEMICAL STUDIES OF ANTIGENS ON MALARIA-INFECTED RED CELLS
疟疾感染红细胞抗原的生物学和生化研究
批准号：
3818148
负责人：
R J HOWARD
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818148
关键词：
Africa Plasmodium falciparum Plasmodium knowlesi antibody formation cell adhesion cellular immunity erythrocyte membrane erythrocytes host organism interaction immunoelectron microscopy intracellular parasitism lactoperoxidase malaria membrane activity membrane proteins microorganism immunology protein biosynthesis protozoal antigen protozoal infection radiotracer surface antigens thrombospondins tissue /cell culture

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英文摘要
We are studying the structure and function of malarial proteins inserted into and through the membrane of erythrocytes infected with mature asexual parasites and molecules on the endothelial cells involved in cytoadherence. Molecular biological approaches are being developed for attempted cloning of the P. knowlesi variant antigen on infected erythrocytes and the P. falciparum protein PfEMP1 that our earlier studies implicated in the cytoadherence property of these cells.
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BIOLOGICAL AND BIOCHEMICAL STUDIES OF ANTIGENS ON MALARIA-INFECTED RED CELLS
BIOLOGICAL AND BIOCHEMICAL STUDIES OF ANTIGENS ON MALARIA-INFECTED RED CELLS
BIOLOGICAL AND BIOCHEMICAL STUDIES OF ANTIGENS ON MALARIA-INFECTED RED CELLS
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