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ALCOHOL ABUSE AND REGIONAL CEREBRAL FUNCTION

酒精滥用与区域大脑功能

基本信息

批准号：
3109271
负责人：
RICHARD A HAWKINS
金额：
$ 13.49万
依托单位：
ROSALIND FRANKLIN UNIV OF MEDICINE & SCI
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-07-01 至 1990-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3109271
关键词：
alcoholism /alcohol abuse beta hydroxybutyrate blood brain barrier brain brain disorders brain mapping brain metabolism drug abuse ethanol glucose glucose metabolism laboratory rat lysine nutrition nutrition related tag phenylalanine radiotracer

项目摘要

The goal of this research is to define some of the physiological and pathological changes that occur in brain due to alcohol abuse. Rats will be used in an experimental model to study the effect of acute and chronic alcohol intoxication. The question whether alcohol selectively affects specific brain structures has never been comprehensively addressed. Most of the observations in man are confused by concomitant nutritional deficiencies. It is not clear whether it is alcohol or malnutrition, or a combination of the two, which is responsible for the well established brain abnormalities associated with chronic alcohol use. The determination of the site of action in vivo is of vital importance to the further understanding of the effect of alcohol as well as providing the basis for the design of future experiments. Therefore, the following will be measured in carefully controlled studies which pay particular attention to nutrition. Regional cerebral metabolism of glucose will be used as a measure of neural function of individual cerebral structures. This will be measured using [6-14C]-glucose as a tracer molecule. Permeability of the blood-brain barrier to four essential nutrients, glucose, phenylalanine, lysine and 3-hydroxybutyrate, will be determined. These are representatives of important transport systems which mediate a delicate balance between supply and need. Disturbances of this balance, which may well occur following alcohol abuse, can have important consequences for cerebral function.

这项研究的目的是定义一些生理和由于酗酒而导致大脑发生病理变化。老鼠会用于实验模型以研究急性和慢性的影响酒精中毒。酒精是否选择性地影响特定大脑结构的问题从未得到全面解决。大多数对人类的观察因伴随的营养缺乏而感到困惑。目前还不清楚无论是酒精还是营养不良，或者两者兼而有之，负责与相关的已确定的大脑异常长期饮酒。体内作用位点的确定是对于进一步了解酒精的影响至关重要并为今后的实验设计提供依据。因此，将在仔细对照的研究中测量以下内容其中特别注重营养。葡萄糖的区域脑代谢将被用作神经功能的测量个体大脑结构的功能。这将使用以下方法测量 [6-14C]-葡萄糖作为示踪分子。血脑屏障对四种必需营养素的渗透性，将测定葡萄糖、苯丙氨酸、赖氨酸和3-羟基丁酸。这些是重要运输系统的代表，它们调解了供给与需求之间的微妙平衡。这种平衡的扰乱，这很可能发生在酗酒后，可能具有重要意义对脑功能的影响。