ALCOHOL ABUSE AND REGIONAL CEREBRAL FUNCTION

这项研究的目的是确定一些生理和 由于酗酒而在大脑中发生的病理变化。 大鼠将 在实验模型中使用，以研究急性和慢性 酒精中毒 酒精是否选择性地影响特定的大脑结构 从来没有得到全面的解决。 对人类的大多数观察 被随之而来的营养缺乏所困扰。 目前尚不清楚 无论是酒精还是营养不良，或者两者兼而有之， 是导致大脑异常的原因， 长期酗酒 体内作用位点的确定是 这对进一步了解酒精的作用至关重要， 并为今后的实验设计提供依据。 因此，将在仔细对照的研究中测量以下内容 特别注重营养。 葡萄糖的局部脑代谢将被用作神经功能的测量。 个体大脑结构的功能。 这将通过以下方式进行测量： [6- 14 C]-葡萄糖作为示踪分子。 血脑屏障对四种必需营养素的渗透性， 将测定葡萄糖、苯丙氨酸、赖氨酸和3-羟基丁酸。 这些都是重要的交通系统的代表， 供需之间的微妙平衡。 打破这种平衡， 这很可能发生在酗酒之后，可能会产生重要的影响 对大脑功能的影响。

The goal of this research is to define some of the physiological and pathological changes that occur in brain due to alcohol abuse. Rats will be used in an experimental model to study the effect of acute and chronic alcohol intoxication. The question whether alcohol selectively affects specific brain structures has never been comprehensively addressed. Most of the observations in man are confused by concomitant nutritional deficiencies. It is not clear whether it is alcohol or malnutrition, or a combination of the two, which is responsible for the well established brain abnormalities associated with chronic alcohol use. The determination of the site of action in vivo is of vital importance to the further understanding of the effect of alcohol as well as providing the basis for the design of future experiments. Therefore, the following will be measured in carefully controlled studies which pay particular attention to nutrition. Regional cerebral metabolism of glucose will be used as a measure of neural function of individual cerebral structures. This will be measured using [6-14C]-glucose as a tracer molecule. Permeability of the blood-brain barrier to four essential nutrients, glucose, phenylalanine, lysine and 3-hydroxybutyrate, will be determined. These are representatives of important transport systems which mediate a delicate balance between supply and need. Disturbances of this balance, which may well occur following alcohol abuse, can have important consequences for cerebral function.