Deciphering how PTEN phosphatase mediates excitotoxic neuronal death
Deciphering how PTEN phosphatase mediates excitotoxic neuronal death
批准号:
nhmrc : 509146
负责人:
A/Pr Heung-Chin Cheng
金额:
$34.65万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2011-12-31
中文摘要
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英文摘要
In stroke patients, oxygen deprivation indirectly induces massive nerve cell death by activating a cell death-promoting enzyme called PTEN. We aim at unravelling (i) how PTEN is activated by oxygen deprivation, (ii) where the activated PTEN is localised in cells, and (iii) how the activated and optimally localised PTEN induces nerve cell death. The study will benefit development of therapeutic strategies to protect against brain damage in stroke.
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会议论文
A new function for an old enzyme: Src Protein Kinase directs excitotoxic neuronal death in stroke
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批准号:nhmrc : 1050486
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项目类别:Project Grants
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资助金额:$34.27万
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财政年份:2013
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负责人:A/Pr Heung-Chin Cheng
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依托单位:
Regulation and substrate identification of Parkinsons disease causative Leucine-rich Repeat Kinase 2 (LRRK2)
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批准号:nhmrc : 566743
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项目类别:NHMRC Project Grants
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资助金额:$46.64万
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财政年份:2009
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负责人:A/Pr Heung-Chin Cheng
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依托单位:
Deciphering the Neuroprotective Mechanism of Parkinsons Disease-Associated Protein Kinase PINK1
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批准号:nhmrc : 566751
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项目类别:NHMRC Project Grants
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资助金额:$36.54万
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财政年份:2009
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负责人:A/Pr Heung-Chin Cheng
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依托单位:
Inhibition of Nef-activated Src-family kinases by CHK
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批准号:nhmrc : 509115
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项目类别:NHMRC Project Grants
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资助金额:$34.29万
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财政年份:2008
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负责人:A/Pr Heung-Chin Cheng
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依托单位:
Novel upstream regulatory and down-stream signaling mechanisms of the Src-family protein kinases
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批准号:nhmrc : 400156
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项目类别:NHMRC Project Grants
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资助金额:$24.25万
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财政年份:2006
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负责人:A/Pr Heung-Chin Cheng
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依托单位:
Regulation of the tumour suppressor PTEN by phosphorylation and oligomerization
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批准号:nhmrc : 208929
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项目类别:NHMRC Project Grants
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资助金额:$16.11万
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财政年份:2002
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负责人:A/Pr Heung-Chin Cheng
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依托单位:
Regulation of SRC-Family and focal adhesion kinase function
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批准号:nhmrc : 114186
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项目类别:NHMRC Project Grants
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资助金额:$25.43万
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财政年份:2000
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负责人:A/Pr Heung-Chin Cheng
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依托单位:
海外基金