层粘连蛋白受体及其在自然杀伤细胞功能中的作用-猫眼课题宝

层粘连蛋白受体及其在自然杀伤细胞功能中的作用

批准号：

3916391

负责人：

G J BRYANT

金额：

$0.0万

依托单位：

DIVISION OF CANCER BIOLOGY AND DIAGNOSIS

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3916391

关键词：

binding proteins hormone receptor humoral immunity laboratory mouse laminin metastasis neoplasm /cancer immunology protein metabolism receptor receptor binding

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英文摘要

Natural killer (NK) cells, a subpopulation of large granular lymphocytes (LGL) are involved in the spontaneous lysing of tumor or virally infected target cells. The killing action requires binding of the killer cells to the target cells. The role of the laminin receptor in this process of specific binding is being examined in our laboratories. Using murine NK cells, the presence of laminin-like molecule and a receptor for laminin binding has been established (Kd 10-11 M, approximately 990,000 receptors/cell). Further studies will attempt to define and compare the receptor on NK cells versus the already established laminin receptor located on many tumor cells; the interactions between these two receptors during cell lysis will be explored.

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