LAMININ RECEPTOR AND ITS ROLE IN THE FUNCTION OF NATURAL KILLER CELLS

层粘连蛋白受体及其在自然杀伤细胞功能中的作用

• 批准号: 3916391
• 负责人: G J BRYANT
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3916391
• 关键词: binding proteins; hormone receptor; humoral immunity; laboratory mouse; laminin; metastasis; neoplasm /cancer immunology; protein metabolism; receptor; receptor binding

Natural killer (NK) cells, a subpopulation of large granular lymphocytes (LGL) are involved in the spontaneous lysing of tumor or virally infected target cells. The killing action requires binding of the killer cells to the target cells. The role of the laminin receptor in this process of specific binding is being examined in our laboratories. Using murine NK cells, the presence of laminin-like molecule and a receptor for laminin binding has been established (Kd 10-11 M, approximately 990,000 receptors/cell). Further studies will attempt to define and compare the receptor on NK cells versus the already established laminin receptor located on many tumor cells; the interactions between these two receptors during cell lysis will be explored.

自然杀伤（NK）细胞，大颗粒亚群