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STRUCTURE AND FUNCTION OF THE ADV GENOME

STRUCTURE AND FUNCTION OF THE ADV GENOME
ADV 基因组的结构和功能
批准号：
3822016
负责人：
M E BLOOM
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3822016
关键词：
Parvoviridae genetic mapping genetic transcription genome molecular cloning nucleic acid sequence tissue /cell culture virulence virus DNA virus antigen virus characteristic virus diseases virus envelope virus genetics virus replication

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英文摘要
The purpose of this project is the study of genome structure and function of the Aleutian disease of mink parvovirus (ADV). In the past year we have completed sequencing of ADV-G genome and found that its overall structure resembles that of other nondefective parvoviruses. A portion of the "left-hand" open reading frame (ORF) has been expressed in bacteria and shown to code for the 71,000 dalton nonstructural protein of ADV. Sequence heterogeneity for the structural protein region of the ADV genome has been demonstrated with the heterogeneity observed might reflect host range determinants involved with pathogenicity. Finally, study of the ADV transcription program has been initiated. Three major polyadenylated RNAs have been detected; 4.5 kb, 2.6 kb, and 0.9 kb.
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PATHOGENESIS OF ALEUTIAN DISEASE VIRUS INFECTION
PATHOGENESIS OF ALEUTIAN DISEASE VIRUS INFECTION
STRUCTURE AND FUNCTION OF THE ADV GENOME
PATHOGENESIS OF ALEUTIAN DISEASE VIRUS INFECTION
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