MECHANISMS OF GLOMERULAR AND TUBULAR INJURY

肾小球和肾小管损伤的机制

• 批准号: 3105853
• 负责人: RICHARD L TANNEN
• 金额: $ 71.89万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105853
• 关键词: glomerulonephritis; nephrosclerosis; renal tubule

The purpose of this Center will be to bring together the different expertise and approaches of individuals working primarily outside the renal area to interact with individuals with a nephrology background to focus on mechanisms of glomerular and tubular injury. In particular, the proposal will address the sequences of events leading from initial immune - mediated glomerular injury through formation of the glomerular crescent to sclerosis of the glomerulars. We will further delineate the biology of the normal tubule and its relation to issues pertinent to tubule injury and will examine how tubules are damaged by immunologic and inflammatory mediators, hypoxia and nephrotoxin. The nephrotoxicity of cyclosporin will be investigated at the cellular, tubular and whole animal level, as well as in man. To accomplish these goals, the Center will comprise 17 investigators participating in 11 projects and 3 Cores. A morphology and administrative Core will support all aspects of the Center while the final core will provide the animal model and cell culture support for the Cresentic Nephritis Components of the Center.

这个中心的目的是将不同的 主要在外面工作的个人的专业知识和方法 与肾脏科相互作用的肾脏区域 专注于肾小球和管状机制的背景 受伤。 特别是，该提案将解决事件的序列 通过初始免疫 - 通过 肾小球新月形成的硬化症 肾小球。 我们将进一步描述正常的生物学 小管及其与与小管损伤有关的问题的关系，将 检查小管如何受到免疫学和 炎症介质，缺氧和肾毒素。 这 环孢菌素的肾毒性将在细胞上研究 管状和整个动物水平以及人类。 为了实现这些目标，该中心将包括17 调查人员参加了11个项目和3个核心。 一个 形态和行政核心将支持 中心虽然最终核心将提供动物模型，并且 细胞培养支持曲肠炎的肾炎成分 中心。