POLYDRUG ABUSE IN WOMEN: NIDA CLINICAL RESEARCH CENTER

女性滥用多种药物：NIDA 临床研究中心

• 批准号: 3105351
• 负责人: JACK H MENDELSON
• 金额: $ 61.08万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105351
• 关键词: drug abuse; drug abuse chemotherapy; female

Drug abuse and drug dependence is the second most common mental health disorder among young women in American today. Recent survey data also indicate that abuse of marihuana, cocaine, tobacco and alcohol by women is increasing. Yet the PHS Task Force on Women's Health Issues (1985) noted that there has been relatively little research on the health consequences of substance use and recommended "studies of the significant factors related to the onset, continuation and cessation of smoking, drinking and drug taking by women". The proposed clinical research center program focuses on the biological and behavioral antecedents, correlates and consequences of substance abuse by women. The safety and efficacy of new pharmacological treatments for cocaine, opiate and polydrug abuse will be evaluated in controlled inpatient and outpatient drug treatment programs. Parallel studies to determine if new pharmacotherapies effectively suppress cocaine self- administration in a female monkey drug self-administration model are proposed. Established operant behavioral procedures will be used to evaluate the dose range of pharmacotherapeutic efficacy and safety. Controlled clinical research ward studies are proposed to examine polydrug use patterns involving marihuana, alcohol and tobacco. Covariance between premenstrual dysphoria and drug use patterns will be examined. Neurobehavioral correlates of the development of tolerance to marihuana during chronic marihuana smoking will also be studied. Neurophysiologic and behavioral correlates of interactions between cocaine, marihuana and alcohol will be examined. Family history of substance abuse has been shown to be a significant factor in risk for polydrug abuse problems. The possible contribution of this antecedent risk factor to marihuana abuse will be evaluated by comparing sensitivity to the physiologic and behavioral effects of marihuana in women with and without a positive family history of alcohol abuse. Implementation of more effective drug abuse treatment programs and improved strategies for drug abuse prevention requires intensive analysis of biologic, behavioral and social concomitants of gender-related and gender specific factors in substance abuse.

药物滥用和药物依赖是第二常见的 精神疾病在美国年轻女性中的流行 最近的调查数据还表明，滥用大麻， 可卡因、烟草和酒精的妇女人数正在增加。 然而 PHS妇女健康问题工作队（1985年）指出， 对健康后果的研究相对较少， 物质使用和建议“的重要因素的研究 与吸烟的开始、持续和停止有关， 妇女酗酒和吸毒”。 拟议的临床研究中心计划的重点是 生物和行为的前因、相关因素和后果 女性滥用药物。 新的安全性和有效性 可卡因、鸦片制剂和多种毒品的药物治疗 滥用将在控制住院和门诊药物 治疗方案。 平行研究，以确定新的 药物疗法有效地抑制可卡因自身 在雌性猴药物自我给药模型中给药 被提议。 既定的操作性行为程序将 用于评价药效的剂量范围 和安全性 对照临床研究病房研究建议检查 涉及大麻、酒精和烟草的多种药物使用模式。 经前焦虑与药物使用模式之间的协方差 将被审查。 神经行为相关的发展 在长期吸食大麻的过程中， 也被研究。 神经生理学和行为学的相关性 可卡因大麻和酒精之间的相互作用 考察 药物滥用的家族史已被证明 是多种药物滥用问题风险的一个重要因素。 的 这种先前的风险因素对大麻的可能贡献 将通过比较敏感性来评估滥用情况 生理和行为的影响，大麻在妇女与 也没有酗酒的家族史 实施更有效的药物滥用治疗方案 和改进预防药物滥用的战略， 对生物、行为和社会并发症的深入分析 药物滥用中与性别有关的因素和与性别有关的因素。