GENETIC PREDISPOSITION TO HYPERTENSION IN DIABETES

糖尿病患者高血压的遗传倾向

• 批准号: 3941002
• 负责人: ANDRZEJ S KROLEWSKI
• 金额: --
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941002
• 关键词: albuminuria; disease /disorder proneness /risk; hemodynamics; human tissue; radioimmunoassay; renal hypertension

Epidemiologic data provide evidence that only one out of three patients with juvenile-onset insulin-dependent diabetes (IDDM) develops renal complications. The pattern of appearance of diabetic nephropathy suggests that the remaining two-thirds are not susceptible. Recently we obtained preliminary data which showed an association between the risk of diabetic nephropathy and genetic predisposition to hypertension. That predisposition might also represent the basis for "susceptibility" to nephropathy in IDDM. This research proposes to investigate the association further and has the following specific aims: 1. To determine whether the risk of diabetic nephropathy is associated with parental hypertension. 2. To determine whether the risk of diabetic nephropathy is associated with a high Vmax for Na-Li countertransport in red blood cells and whether this risk is independent of the risk conferred by the presence of hypertension in parents. 3. To determine whether the risk of diabetic nephropathy is associated with the Vmax of Na, K-ATPase in red blood cells. 4. To determine whether the risk factors postulated above have a major role in the development of microalbuminuria, in the progression of it to overt proteinuria, or in both. 5. The findings will provide a basis for developing preventive programs against the development of renal complications in IDDM.

流行病学数据提供的证据表明，只有三分之一的人 青少年发病的胰岛素依赖型糖尿病（IDDM）患者 出现肾脏并发症。 外观图案 糖尿病肾病表明剩下的三分之二是 不敏感。 近期我们获得了初步数据 表明糖尿病肾病的风险之间存在关联 以及高血压的遗传倾向。 那种倾向 也可能代表对肾病“易感性”的基础 在 IDDM 中。 本研究旨在调查该协会 进一步并具有以下具体目标： 1. 判断是否有患糖尿病肾病的风险 与父母高血压有关。 2. 判断是否有患糖尿病肾病的风险 与红色的 Na-Li 反向转运的高 Vmax 相关 血细胞以及该风险是否独立于风险 父母患有高血压所致。 3. 判断是否有患糖尿病肾病的风险 与红细胞中 Na、K-ATP 酶的 Vmax 相关。 4. 确定上述假设的危险因素是否具有 在微量白蛋白尿的发生过程中起重要作用 进展为明显的蛋白尿，或两者兼而有之。 5. 研究结果将为制定预防措施提供依据 预防肾脏并发症发展的计划 IDDM。