GENETIC PREDISPOSITION TO HYPERTENSION IN DIABETES

糖尿病患者高血压的遗传倾向

• 批准号: 3855098
• 负责人: ANDRZEJ S KROLEWSKI
• 金额: --
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3855098
• 关键词: albuminuria; diabetic nephropathy; disease /disorder proneness /risk; hemodynamics; human tissue; insulin dependent diabetes mellitus; radioimmunoassay; renal hypertension

Epidemiologic data provide evidence that only one out of three patients with juvenile-onset insulin-dependent diabetes (IDDM) develops renal complications. The pattern of appearance of diabetic nephropathy suggests that the remaining two-thirds are not susceptible. Recently we obtained preliminary data which showed an association between the risk of diabetic nephropathy and genetic predisposition to hypertension. That predisposition might also represent the basis for "susceptibility" to nephropathy in IDDM. This research proposes to investigate the association further and has the following specific aims: 1. To determine whether the risk of diabetic nephropathy is associated with parental hypertension. 2. To determine whether the risk of diabetic nephropathy is associated with a high Vmax for Na-Li countertransport in red blood cells and whether this risk is independent of the risk conferred by the presence of hypertension in parents. 3. To determine whether the risk of diabetic nephropathy is associated with the Vmax of Na, K-ATPase in red blood cells. 4. To determine whether the risk factors postulated above have a major role in the development of microalbuminuria, in the progression of it to overt proteinuria, or in both. 5. The findings will provide a basis for developing preventive programs against the development of renal complications in IDDM.

流行病学数据表明，只有三分之一的人 青少年胰岛素依赖型糖尿病（IDDM）患者 出现肾脏并发症 出现的模式 糖尿病肾病的发病率有三分之二。 不易受影响。 最近，我们获得了初步数据， 显示糖尿病肾病的风险 和高血压的遗传易感性。 这种倾向 也可能是肾病“易感性”的基础 胰岛素依赖型糖尿病 本研究拟探讨 并有以下具体目标： 1. 要确定糖尿病肾病的风险是否 与父母高血压有关。 2. 要确定糖尿病肾病的风险是否 与红色中Na-Li反向转运的高Vmax相关 血细胞以及这种风险是否独立于 这是由于父母患有高血压。 3. 要确定糖尿病肾病的风险是否 与红细胞Na，K-ATP酶Vmax有关。 4. 为了确定上述假设的风险因素是否具有 在微量白蛋白尿的发展中起主要作用， 进展为明显的蛋白尿，或两者兼有。 5. 研究结果将为制定预防措施提供依据 预防肾脏并发症的发展计划， 胰岛素依赖型糖尿病。