GENETIC PREDISPOSITION TO HYPERTENSION IN DIABETES

流行病学数据提供的证据表明，只有三分之一的人 幼年型胰岛素依赖型糖尿病(IDDM)患者 会出现肾脏并发症。…的外观图案 糖尿病肾病表明，剩下的三分之二是 不容易受影响。最近我们得到了初步的数据， 表明糖尿病肾病的风险与 以及高血压的遗传易感性。这种易感性 也可能是肾病“易感性”的基础 在IDDM中。这项研究建议调查这种联系 并有以下具体目标： 1.确定糖尿病肾病的风险是否 与父母高血压有关。 2.确定糖尿病肾病的风险是否 与红色的Na-Li反向转运的高Vmax有关 以及这种风险是否独立于风险 这是由于父母中存在高血压所致。 3.确定糖尿病肾病的风险是否 与红细胞中Na，K-ATPase的Vmax相关。 4.确定上述假设的风险因素是否具有 在微量白蛋白尿的发展中起主要作用 进展为明显蛋白尿，或两者兼而有之。 5.研究结果将为制定预防措施提供依据 年针对肾脏并发症发展的方案 IDDM。

Epidemiologic data provide evidence that only one out of three patients with juvenile-onset insulin-dependent diabetes (IDDM) develops renal complications. The pattern of appearance of diabetic nephropathy suggests that the remaining two-thirds are not susceptible. Recently we obtained preliminary data which showed an association between the risk of diabetic nephropathy and genetic predisposition to hypertension. That predisposition might also represent the basis for "susceptibility" to nephropathy in IDDM. This research proposes to investigate the association further and has the following specific aims: 1. To determine whether the risk of diabetic nephropathy is associated with parental hypertension. 2. To determine whether the risk of diabetic nephropathy is associated with a high Vmax for Na-Li countertransport in red blood cells and whether this risk is independent of the risk conferred by the presence of hypertension in parents. 3. To determine whether the risk of diabetic nephropathy is associated with the Vmax of Na, K-ATPase in red blood cells. 4. To determine whether the risk factors postulated above have a major role in the development of microalbuminuria, in the progression of it to overt proteinuria, or in both. 5. The findings will provide a basis for developing preventive programs against the development of renal complications in IDDM.