NEUROENDOCRINOLOGY OF REPRODUCTION AND GROWTH

生殖和生长的神经内分泌学

• 批准号: 3106133
• 负责人: ROGER C. GUILLEMIN
• 金额: $ 108.38万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-06-30 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106133
• 关键词: growth factor; hypothalamic pituitary axis; neuroendocrine system

A Program Project which proposes: 1) To complete the isolation, molecular characterization and synthesis of a novel pituitary and placental protein, mesotrophin, or mesodermal growth factor (MGF) present in bovine and human pituitaries and human placenta; 2) To ascertain the biology and role of MGF in function of the corpus luteum, implantation and fetal developmnt; 3) To elucidate the nature of the hypothalamic control of the secretion of MGF which we already have demonstrated to exist; 4) Complete the isolation, characterization and synthesis of inhibin of follicular fluid origin; 5) To ascertain the biology of follicular inhibin(s); 6) To elucidate the nature of follicular peptides regulating follicular sensitivity to gonadotropins; 7) To pursue physiological studies with synthetic GRF (growth hormone releasing factor or somatocrinin), in vivo and in vitro; 8) To isolate, characterize and synthesize pituitary factors (other than ACTH) involved in control of pubertal adrenal androgenesis; 9) To improve the sensitivity of the current methodology for characterization of peptides; 10) To maintain or expand the current methodology for peptide synthesis; 11) To maintain and expand the current methodology for radioimmunoassays and immunotechniques; the latter three projects as part of core supports within the Program.

一个计划项目，提出：1）完成分离，分子， 新型垂体和胎盘蛋白的表征和合成， 存在于牛和人中的中胚层生长因子（MGF 2）明确MGF的生物学特性和作用 在黄体功能、着床和胎儿发育中的作用; 3） 阐明下丘脑控制MGF分泌的本质 我们已经证明了它的存在; 4）完成隔离， 卵泡液来源的卵泡素的表征和合成; 5） 确定滤泡性白蛋白的生物学特性; 6）阐明其性质， 卵泡肽调节卵泡对促性腺激素的敏感性; 7)用合成的GRF（生长激素）进行生理研究 释放因子或生长激素分泌素）; 8）为了分离， 表征和合成垂体因子（ACTH除外）， 控制青春期肾上腺雄激素生成; 9）提高敏感性 目前用于表征肽的方法; 10）为了维持 或扩展目前的肽合成方法; 11）维持 并扩展了放射免疫测定的现有方法， 免疫技术;后三个项目作为核心支持的一部分， 节目