MOLECULAR REGULATION OF GROWTH AND DEVELOPMENT

生长和发育的分子调控

• 批准号: 3103144
• 负责人: IAN M BURR
• 金额: $ 29.24万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103144
• 关键词: biomedical facility; child health care personnel; genetic techniques; molecular genetics; physicians; training

To provide resources and facilitate the transfer of knowledge gained through studies in clinical applications of basic science methodologies, a cohort of established Pediatric investigators and established investigators in basic science departments at Vanderbilt whose research address issues of normal and perturbed ontogeny will pool their experience, talents and resources to establish a Child Health Research Center that provides shared CORE Laboratories and training for Junior Pediatric faculty. The theme of the Vanderbilt CHRC, molecular regulation of growth and development, was chosen to intensify and expand studies of the mechanisms that control normal growth and function at a molecular level. Perturbation of molecular regulation by genetic or environmental factors potentially contributes to all disease processes, particularly those affecting children. Furthermore, better understanding of molecular regulation will provide insights to our understanding, diagnosis and treatment of diseases that affect children. Our overall goal is to contribute to the understanding of the molecular mechanisms that regulate cell and tissue growth and function in normal and deranged development. To achieve this goal we plan the following specific aims: 1) develop an administrative and organizational structure to support the Vanderbilt CHRC, 2, enhance the quality and productivity of all CHRC investigators by facilitating access to current concepts and techniques applicable to studies of the molecular bases of disease pathogenesis, (3) support research initiatives by Junior Pediatric faculty in studying diseases of childhood that perturb normal growth and development at a molecular level, 4) support new initiatives in research by Junior Pediatric faculty through provision and access to New Project Development Awards, and 5) recruit and foster the development of research skills of Pediatric oriented medical students, residents, follows and Junior faculty. Realization of these specific aims will increase the understanding of normal growth and development as well as disease processes by Junior Pediatric faculty and enhance their development as independent investigators. The technology and concepts involved in molecular analysis apply to a majority of Pediatric disciplines where molecular, physiological, cell biology and biochemical studies are needed to gain complete insight to regulation in normal and pathologic processes.

提供资源并促进所获得知识的转移 通过基础科学方法的临床应用研究， 已建立的儿科研究人员队列和已建立的研究人员 在范德比尔特大学基础科学系工作，其研究解决了以下问题 正常和受干扰的个体发育将汇集他们的经验、才能和 资源建立儿童健康研究中心，提供共享 核心实验室和初级儿科教师培训。 主题为 范德比尔特 CHRC（生长和发育的分子调节） 选择加强和扩大对控制机制的研究 分子水平上的正常生长和功能。 分子扰动 遗传或环境因素的调节可能有助于 所有疾病过程，特别是影响儿童的疾病过程。 此外， 更好地理解分子调控将为我们提供见解 了解、诊断和治疗影响儿童的疾病。 我们的总体目标是促进对分子的理解 调节细胞和组织正常和功能生长和功能的机制 发育紊乱。 为实现这一目标，我们具体规划如下 目标：1）建立行政和组织结构来支持 范德比尔特 CHRC，2、提高所有 CHRC 的质量和生产力 通过促进研究人员获取当前的概念和技术 适用于疾病发病机制的分子基础研究，(3) 支持初级儿科教师的研究倡议 影响儿童正常生长发育的疾病 分子水平，4）支持初级儿科研究的新举措 教师通过提供和获得新项目开发奖，以及 5）招募和培养儿科研究技能的发展 面向医学生、住院医师、追随者和初级教员。 实现这些具体目标将加深对以下方面的理解： Junior 的正常生长发育以及疾病过程 儿科教师并加强其独立发展 调查人员。 分子分析涉及的技术和概念 适用于分子、 需要进行生理学、细胞生物学和生化研究才能获得 对正常和病理过程的调节有完整的了解。