MOLECULAR REGULATION OF GROWTH AND DEVELOPMENT

生长和发育的分子调控

• 批准号: 3103145
• 负责人: IAN M BURR
• 金额: $ 27.74万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3103145
• 关键词: biomedical facility; child health care personnel; genetic techniques; molecular genetics; physicians; training

To provide resources and facilitate the transfer of knowledge gained through studies in clinical applications of basic science methodologies, a cohort of established Pediatric investigators and established investigators in basic science departments at Vanderbilt whose research address issues of normal and perturbed ontogeny will pool their experience, talents and resources to establish a Child Health Research Center that provides shared CORE Laboratories and training for Junior Pediatric faculty. The theme of the Vanderbilt CHRC, molecular regulation of growth and development, was chosen to intensify and expand studies of the mechanisms that control normal growth and function at a molecular level. Perturbation of molecular regulation by genetic or environmental factors potentially contributes to all disease processes, particularly those affecting children. Furthermore, better understanding of molecular regulation will provide insights to our understanding, diagnosis and treatment of diseases that affect children. Our overall goal is to contribute to the understanding of the molecular mechanisms that regulate cell and tissue growth and function in normal and deranged development. To achieve this goal we plan the following specific aims: 1) develop an administrative and organizational structure to support the Vanderbilt CHRC, 2, enhance the quality and productivity of all CHRC investigators by facilitating access to current concepts and techniques applicable to studies of the molecular bases of disease pathogenesis, (3) support research initiatives by Junior Pediatric faculty in studying diseases of childhood that perturb normal growth and development at a molecular level, 4) support new initiatives in research by Junior Pediatric faculty through provision and access to New Project Development Awards, and 5) recruit and foster the development of research skills of Pediatric oriented medical students, residents, follows and Junior faculty. Realization of these specific aims will increase the understanding of normal growth and development as well as disease processes by Junior Pediatric faculty and enhance their development as independent investigators. The technology and concepts involved in molecular analysis apply to a majority of Pediatric disciplines where molecular, physiological, cell biology and biochemical studies are needed to gain complete insight to regulation in normal and pathologic processes.

提供资源并促进所获知识的转让 通过基础科学方法论的临床应用研究， 已确定的儿科研究人员和已确定的研究人员队列 在范德比尔特的基础科学部门，他们的研究解决了 正常和不安的个体发育将汇集他们的经验、才华和 用于建立儿童健康研究中心的资源，该中心提供共享 儿科初级教员的核心实验室和培训。的主题 范德比尔特CHRC，生长和发育的分子调控，是 选择加强和扩大对控制机制的研究 在分子水平上正常生长和功能。分子的微扰 遗传或环境因素的调节可能有助于 所有疾病进程，特别是那些影响儿童的进程。此外， 更好地理解分子调控将为我们的 了解、诊断和治疗影响儿童的疾病。 我们的总体目标是有助于理解分子 调节细胞和组织生长和功能的机制 错乱的发展。为了实现这一目标，我们计划采取以下具体措施 目标：1)建立行政和组织结构，以支持 范德比尔特CHRC，2，提高所有CHRC的质量和生产力 通过促进对当前概念和技术的获取，调查人员 适用于疾病发病的分子基础研究，(3) 支持初级儿科教员在学习中的研究倡议 儿童时期的疾病，扰乱儿童的正常生长和发育 分子水平，4)支持青少年儿科研究的新举措 通过提供和获得新项目开发奖的教师，以及 5)招募和促进儿科科研技能发展 面向医学生、住院医生、跟随者和初级教员。 这些具体目标的实现将增加对 青少年的正常生长发育和疾病过程 加强儿科教师的自主发展 调查人员。分子分析中涉及的技术和概念 适用于大多数儿科学科，其中分子， 需要进行生理、细胞生物学和生化研究才能获得 对正常和病理过程中的调节有全面的了解。