CENTER FOR REPRODUCTIVE BIOLOGY RESEARCH

本提案的总体目标是继续支持 范德比尔特大学现有一个跨部门，多学科 生殖生物学研究中心。 中心的持续支持 将保持目前许多与人口有关的项目的效率 在范德比尔特，并将允许在一个新的地区发展，目前还没有 表示。 该中心的研究目标包括调查 男性生殖生理学（精子产生，精子生物化学， 精子成熟，精子获能，男性避孕的发展， 男性性行为的神经内分泌控制），对女性生殖 生理学（受精和着床），生殖内分泌学， 增长是一种分化。 请求为一项行政支助 核心单位和八个核心设施（组织学/显微镜检查、电子 显微镜检查，细胞培养/生长因子，激素测定，有机 化学/前列腺素，蛋白质化学，糖蛋白和分子 生物学）和两个程序开发（XY性别的分子分析 在小鼠中的抑制和在小鼠中生长与分化的关系 Mammotrope）。

The overall objective of this proposal is to continue the support at Vanderbilt University of an existing interdepartmental, multidisciplinary Reproductive Biology Research Center. The continuous support of the Center will maintain the efficiency of many population related projects now active at Vanderbilt and will permit development in a new area not presently represented. The research objectives of the Center include investigations on male reproductive physiology (sperm production, sperm biochemistry, sperm maturation, sperm capacitation, development of male contraception, and neuroendocrine control of male sexual behavior), on female reproductive physiology (fertilization and implantation), on reproductive endocrinology, and growth an differentiation. Support is requested for an Administrative Core unit and eight core facilities (Histology/Photomicroscopy, Electron Microscopy, Cell Culture/Growth Factors, Hormone Assay, Organic Chemistry/Prostaglandin, Protein Chemistry, Glycoprotein, and Molecular Biology) and two Program Developments (Molecular Analysis of XY Sex Reversal in the Mouse and Relation of Growth to Differentiation in the Mammotrope).