NATURAL HISTORY STUDIES: GBS AND PNEUMOCOCCAL INFECTION

自然史研究：GBS 和肺炎球菌感染

• 批准号: 2197538
• 负责人: BARRY M GRAY
• 金额: $ 66.96万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2197538
• 关键词: Streptococcus agalactiae; Streptococcus infection; Streptococcus pneumoniae; bactericidal immunity; communicable disease transmission

The objective of this renewal program is to further explore the natural history of infections caused by Streptococcus pneumoniae, group B streptococcus (GBS), and Hemophilus influenzae type b. These three pathogens account for most serious bacterial infection in infants and children and remain significant causes of disease in otherwise healthy young women (GBS puerpural infections) and in aging adults (the pneumococcus). They share many biological and immunological features, and their disease potential has continued to be high, despite advances in antibiotic therapy and development of vaccines. Satisfactory modes of prevention have yet to be realized. This program will focus upon key aspects of host- parasite relationships that may help explain the development of disease and suggest new approaches to its prevention The Core Project provides clinical support for the entire program. While continuing to yield important epidemiologic information through new and ongoing clinical studies, it provides essential patient materials, bacterial isolates, and epidemiological data from well defined patient populations. Seroepidmeiological investigations Project 1 will make use of these materials to more precisely define "protection" in immunological terms. Its studies will evaluate functional (opsonophagocytic) antibody with respect to measured properties, critically examining the roles of avidity and blocking by specific IgA antibodies. Studies of antibody functions other than opsonization will focus upon the activation of platelets and neutrophils in vitro and in acute disease. The immunochemistry of GBS polysaccharides will be studied in Project 2. The similarities between GBS antigens and glycoconjugates of the human host will be examined in relation to colonization and disease. The molecular basis for these similarities will be studied with modern NMR techniques, monoclonal antibodies, and chemically modified GBS antigens: The concept of "virulence" will be examined with respect to biological properties of the bacteria and their polysaccharide capsules. Project 3 will study the surface protein antigens of the pneumococci to develop a protein typing system and to evaluate the possible application of surface proteins as candidate vaccines. The epidemiology of surface protein--will be studied in correlation with the human antibody response to pneumococcal colonization and disease.

这个更新计划的目标是进一步探索

项目成果

Role of adherence of Streptococcus pneumoniae in acute otitis media.

肺炎链球菌粘附在急性中耳炎中的作用。

• DOI: 10.1097/00006454-198807000-00005
• 发表时间: 1988
• 期刊: The Pediatric infectious disease journal
• 作者: Andersson,B;Gray,BM;DillonJr,HC;Bahrmand,A;Edén,CS
• 通讯作者: Edén,CS

IgA antibody to group specific polysaccharide in secretions of carriers and noncarriers of group B streptococci.

针对 B 族链球菌携带者和非携带者分泌物中特定多糖的 IgA 抗体。

• 发表时间: 1987
• 期刊: Advances in experimental medicine and biology
• 作者: Marxmiller,JN;Gray,BM;Anthony,BF
• 通讯作者: Anthony,BF

Hemodynamic responses of chronically instrumented piglets to bolus injections of group B streptococci.

长期仪器仔猪对 B 族链球菌推注的血流动力学反应。

• DOI: 10.1203/00006450-198801000-00018
• 发表时间: 1988
• 期刊: Pediatric research
• 影响因子: 3.6
• 作者: Philips3rd,JB;Lyrene,RK;Godoy,G;Graybar,G;Barefield,E;Sams,JE;Gray,BM
• 通讯作者: Gray,BM

Type-specific antibody prevents platelet aggregation induced by group B streptococci type III.

类型特异性抗体可防止 III 型 B 族链球菌诱导的血小板聚集。

• 发表时间: 1986
• 期刊: The Journal of laboratory and clinical medicine
• 作者: Wood,EG;Gray,BM
• 通讯作者: Gray,BM

Antibodies to Streptococci pneumoniae in sera and secretions of mothers and their infants.

母亲及其婴儿的血清和分泌物中的肺炎链球菌抗体。

• DOI: 10.1007/978-1-4615-3838-7_43
• 发表时间: 1991
• 期刊: Advances in experimental medicine and biology
• 作者: Gray,BM;PolhillJr,RB;Reynolds,DW
• 通讯作者: Reynolds,DW