THREADING PROTIEN SEQUENCE THROUGH FOLDING MOTIF
THREADING PROTIEN SEQUENCE THROUGH FOLDING MOTIF
批准号:
3845098
负责人:
S H BRYANT
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
这个项目的目标是开发优化对齐的算法
英文摘要
The goal of this project is to develop algorithms for optimally aligning
amino acid sequences with protein folding motifs. Folding motifs are
alternative polypeptide backbone conformations, represented in the
computer as lists of pairwise residue contacts. Alignments of sequence
and folding motif are scored using residue contact potentials, or
empirical free energy functions. Optimal alignments may be found by
enumeration of all possibilities, but we wish to develop rapid methods
suitable for search of a conformer data base. We have developed statistics
which adjust for the effects of amino acid composition and sequence length
on expected alignment scores. These provide a quantitative basis for
ranking alternative alignments. We have also found thatpairwise contact
potentials may be partitioned into linear and quadratic terms,
corresponding to the hydrophobic and pairwise components of residue
contact potentials. The hydrophobic term is particularly important in
alignment scores, contributing roughly 2/3 of the information. Using
exhaustive enumeration we have also found that scores from linear and
quadratic components are highly correlated. Together, these observations
suggest that optimal alignments may be identified rapidly by implicit
enumeration. We may use dynamic programming algorithms to rapidly rank
alternative alignments with respect to hydrophobic complementarity, and
then compute pairwise contact complementarity for only thebest alignments
identified. This project may lead to a new and practical method for
protein structure prediction, prediction by recognition of folding motif.
It is applicable to sequences showing little or no homology with other
proteins. Motif recognition may thus detect distant evolutionary
relationships, where sequence similarity is low, and may and extend
possibilities for molecular modeling.
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STRUCTURE PREDICTION BY PROTEIN THREADING
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批准号:5203626
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
DATABASES FOR MOLECULAR MODELING
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批准号:5203627
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
METHODS FOR COMPARISON OF PROTEIN THREE DIMENSIONAL STRUCTURE
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批准号:2578631
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
ANALYSIS OF PACKING CONTACTS IN PROTEIN CRYSTALS
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批准号:3781258
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
EMPIRICAL ENERGY FUNCTIONS FOR MOLECULAR MODELING
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批准号:3845097
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
ANALYSIS OF PACKING CONTACTS IN PROTEIN CRYSTALS
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批准号:3759296
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
PROTEIN THREADING METHODS
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批准号:6162796
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
INTERNET RESOURCES FOR MOLECULAR 3D STRUCTURE
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批准号:6162797
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
DATABASES FOR MOLECULAR MODELING
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批准号:3781279
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
METHODS FOR COMPARISON OF PROTEIN THREE DIMENSIONAL STRUCTURE
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批准号:5203629
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
STRUCTURE PREDICTION BY PROTEIN THREADING
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批准号:3781278
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
STRUCTURE PREDICTION BY PROTEIN THREADING
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批准号:3759315
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
DATABASES FOR MOLECULAR MODELING
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批准号:3759316
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
DATABASES FOR MOLECULAR MODELING
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批准号:2578630
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
PROTEIN THREADING METHODS
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批准号:2578629
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
COMPUTER SOFTWARE FOR ANALYSIS OF PROTEIN THREE-DIMENSIONAL STRUCTURE
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批准号:3845099
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
ANALYSIS OF PACKING CONTACTS IN PROTEIN CRYSTALS
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批准号:3845100
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
PROTEIN 3D STRUCTURE COMPARISON
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批准号:6162798
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
METHODS FOR COMPARISON OF PROTEIN THREE DIMENSIONAL STRUCTURE
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批准号:3759325
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:S H BRYANT
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依托单位:
海外基金