CHIMERIC MONOCLONAL ANTI-GD2 ANTIBODY 14.18 IN METASTATIC MELANOMA

嵌合单克隆抗 GD2 抗体 14.18 用于治疗转移性黑色素瘤

• 批准号: 3847305
• 负责人: MANSOOR N SALEH
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3847305
• 关键词: human subject; human therapy evaluation; melanoma; metastasis; monoclonal antibody; neoplasm /cancer immunotherapy

Monoclonal antibodies can detect a number of antigens which are expressed by cancer cells. Tumor surface antigens present themselves as potential targets for mca therapy. Mca's directed against these tumor surface markers could be useful in treatment of metastatic cancer by preventing attachment of circulating malignant cells and through immune mediated tumor cell destruction.

单抗可以检测到许多表达的抗原。 被癌细胞杀死。肿瘤表面抗原呈现出潜在的 大脑中动脉治疗的靶点。MCA针对这些肿瘤表面 标记物可以通过预防和治疗转移性癌症 循环中恶性肿瘤细胞的黏附及通过免疫介导的肿瘤 细胞毁灭。